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Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance 期刊论文

编号：

04898a65-16a0-4037-afe4-397a4aaff12b
作者：

Zhang, Chao#^[1]Hua, Rui(华瑞)#^[2]Cui, Yuanyuan^[2];Wang, Shasha^[2];Yan, Hongqing(闫红青)^[2]Li, Dongmei(李冬梅)^[2]Zhang, Yonghong^[3];Tu, Zhengkun(涂正坤)^[4]Hao, Pei^[5];Chen, Xinyue^[3];Zhong, Jin^[6];Niu, Junqi(牛俊奇)^[2,4]Jin, Xia(金侠)*^[1]
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2017 年 12 卷 2 期 ; FEB 7
收录：
摘要：

Elucidating protective immunity against HCV is important for the development of a preventative vaccine. We hypothesize that spontaneous resolution of acute HCV infection offers clue to protective immune responses, and that DAA therapy affects the quality and quantity of HCV-specific T cell responses. To test these hypotheses, we performed T cell epitope mapping in 111 HCV-infected individuals including 61 chronically HCV-1b (CHC-1b) infected, 24 chronically HCV-2a (CHC-2a) infected and 26 spontaneously recovered (SPR) patients with 376 overlapping peptides covering the entire HCV polyprotein. Selected T cell epitopes were then used to evaluate T cell responses in another 22 chronically HCV-1b infected patients on DAA therapy. Results showed that SPR had better HCV-specific T cell responses than CHC, as manifested by higher response rate, greater magnitude and broader epitope coverage. In addition, SPR recognized novel epitopes in Core, E1, E2, NS4B, NS5A regions that were not present in the CHC. Furthermore, during the first 24 weeks of DAA therapy, there was no functional immune reconstitution of HCV-specific T cells. These results indicate that T cell responses may be a correlate of protection. Therefore, effective preventative vaccines should elicit a robust T cell response. Although various DAA regimens efficiently cleared viruses from the blood of HCV-infected patients, there was no contemporaneous early T cell immune reconstitution, suggesting that early treatment is needed for preserving the functions of HCV-specific T cells.
推荐引用方式
GB/T 7714：

Zhang Chao,Hua Rui,Cui Yuanyuan, et al. Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance [J].PLOS ONE,2017,12(2).
APA：

Zhang Chao,Hua Rui,Cui Yuanyuan,Wang Shasha,&Jin Xia.(2017).Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance .PLOS ONE,12(2).
MLA：

Zhang Chao, et al. "Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance" .PLOS ONE 12,2(2017).
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