Alpha-fetoprotein (AFP) producing gastric adenocarcinoma is considered as a rare subtype of gastric adenocarcinoma. Compared with AFP non-producing gastric adenocarcinoma, our study and other previous studies showed that AFP producing gastric adenocarcinoma is more aggressive and prone to liver metastasis. Using the Protein Pathway Array, 11 of out of 286 proteins tested were found to be differentially expressed between AFP producing (n=32) and AFP non-producing (n=45) gastric adenocarcinoma tissues. In addition, the high level expression of XIAP and IGF-Ir beta in gastric adenocarcinoma tissues was independent factors for poor prognosis in AFP producing gastric adenocarcinoma patients. A risk model based on the XIAP and IGF-Ir beta expression levels can separate AFP producing gastric adenocarcinoma patients into 2 subgroups and each subgroup had a distinct set of signaling pathways involved. In conclusion, AFP producing gastric adenocarcinoma is a heterogeneous cancer with different clinical outcomes, biological behaviors and underlying molecular alterations.
[1]Jilin Univ, Hosp 1, Dept Gastrointestinal Surg, Changchun 130023, Peoples R China.
[2]Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY 10029 USA.
[3]Jilin Univ, Hosp 1, Dept Clin Lab, Changchun 130023, Peoples R China.
[4]Icahn Sch Med Mt Sinai, Dept Nephrol, New York, NY 10029 USA.
[5]NYU, Sch Med, Dept Pathol, New York, NY USA.
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