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RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells 期刊论文

编号：

0add0314-57cc-4968-97b1-b3510228036d
作者：

Xu, Weiling(徐卫玲)#^[1,2]Gong, Fangchao(宫方超)^[3]Zhang, Ting(张婷)^[4]Chi, Baorong(迟宝荣)*^[1]Wang, Jingyu(王景宇)*^[2]
语种：

英文
期刊：

BIOTECHNOLOGY LETTERS ISSN：0141-5492 2017 年 39 卷 9 期 (1359 - 1367) ; SEP
收录：
关键词：

Cancer stem cell Dnd1 Hepatocellular carcinoma Hippo LATS2
摘要：

To investigate the roles of Dead end 1 (Dnd1) in modulating cancer stem cell-related traits of hepatocellular carcinoma (HCC).
Dead end (Dnd1) inhibited spheroid formation, suppressed the expression of stemness-related genes, and increased sensitivity to sorafenib in HCC cells. Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. As a result, epithelial-mesenchymal transition (EMT) was weakened and therefore the generation of HCC stem cell properties was suppressed.
Dnd1 functions as a tumor suppressor by prohibiting CSC-like characteristics via activating Hippo pathway in HCC cells. Dnd1 could thus be a novel therapeutic target for HCC patients.
推荐引用方式
GB/T 7714：

Xu Weiling,Gong Fangchao,Zhang Ting, et al. RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells [J].BIOTECHNOLOGY LETTERS,2017,39(9):1359-1367.
APA：

Xu Weiling,Gong Fangchao,Zhang Ting,Chi Baorong,&Wang Jingyu.(2017).RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells .BIOTECHNOLOGY LETTERS,39(9):1359-1367.
MLA：

Xu Weiling, et al. "RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells" .BIOTECHNOLOGY LETTERS 39,9(2017):1359-1367.
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