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Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection 期刊论文

编号：

0b0d4470-6702-46f0-b504-821ab4407555
作者：

Wang, Xu#^[1]Wang, Song(王颂)^[2]Liu, ZhenHua^[1];Qi, WenQian^[1];Zhang, Qian^[1];Zhang, YongGui^[1];Sun, DeRong^[3,4];Xu, Yan^[1];Wang, HongGuang^[5];Li, ZhongXie^[6];Cong, XianLing^[7];Zhao, Ping^[1];Zhou, ChangYu^[1];Wang, JiangBin(王江滨)*^[1]
语种：

英文
期刊：

WORLD JOURNAL OF GASTROENTEROLOGY ISSN：1007-9327 2018 年 24 卷 20 期 (2191 - 2202) ; MAY 28
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摘要：

AIM To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus (HCV) infection (OCI). METHODS one hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection (CHC) were diagnosed at five Liver Centers in Northeastern China, from 2012 to 2016. CXCL10 rs1439490, rs1440802, and IL-28B rs12979860 were analyzed by sequencing. Serum CXCL10 was measured by ELISA. Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring. Liver necroinflammation and fibrosis were scored according to the METAVIR system. RESULTS CXCL10 rs1439490 G/G was more prevalent in OCI patients (n = 93/103; 90.3%) than in CHC patients (n = 116/155; 74.8%; P = 0.008). OCI patients had lower serum CXCL10 levels than CHC patients (192.91 +/- 46.50 pg/mL vs 354.78 +/- 102.91 pg/mL, P < 0.0001). Of IL-28B rs12979860 C/C patients, OCI patients with rs1439490 G/G had lower serum and liver levels of CXCL10 and lower levels of liver necroinflammation and fibrosis than non-G/G patients. OCI patients had higher alanine aminotransferase normalization rates after Peg-interferon treatment than CHC patients (P < 0.05) and serum CXCL10 decreased significantly (P < 0.0001). Liver necroinflammation and fibrosis were alleviated in 8 OCI patients after treatment. Multivariate analysis indicated that rs1439490 G/G significantly influenced the occurrence of OCI in HCV infection (OR = 0.31, 95% CI: 0.15-0.66, P = 0.002). CONCLUSION CXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome.
推荐引用方式
GB/T 7714：

Wang Xu,Wang Song,Liu Zhen-Hua, et al. Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection [J].WORLD JOURNAL OF GASTROENTEROLOGY,2018,24(20):2191-2202.
APA：

Wang Xu,Wang Song,Liu Zhen-Hua,Qi Wen-Qian,&Wang Jiang-Bin.(2018).Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection .WORLD JOURNAL OF GASTROENTEROLOGY,24(20):2191-2202.
MLA：

Wang Xu, et al. "Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection" .WORLD JOURNAL OF GASTROENTEROLOGY 24,20(2018):2191-2202.
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