Nanocomposites based on hollow Au nanostructures have gained considerable attention in theranostics applications because of their unique plasmonic structures and attractive physicochemical properties. The exploration of feasible and facile methods for constructing multifunctional nano composites combined with bioactive molecules is greatly needed for the development of multifunctional theranostics platforms. In this work, resveratrol, a natural polyphenol with antioxidant activity and cancer-chemopreventive propertyies is employed as the reducing agent cum coating agent for the surfactant-free preparation of Au@resveratrol hollow NPs (Au@Res HNPs). The as-prepared Au@Res HNPs were found to present good photothermal performance and chemical inhibition for cancer therapy. In vitro experiments indicated that the Au@Res HNPs can block cell cycles to inhibit cell division and lead to cell apoptosis after 808-nm laser irradiation. Because no toxic surfactants are introduced, the current protocol avoids the tedious surfactant separation and surface modification processes that are necessary for most theranostics materials.
[1]Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China.
[2]Jilin Univ, Inst Atom & Mol Phys, Changchun 130012, Peoples R China.
[3]Jilin Univ, Sch Stomatol, Changchun 130041, Peoples R China.
[4]Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
(8.0+极速模式)