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Circulating CD14(+)CD163(+)CD115(+) M2 monocytes are associated with the severity of new onset severe acute pancreatitis in Chinese patients 期刊论文

编号：

0cd00bd9-2306-41c5-923a-e43ff1bb626c
作者：

Zhang, Manli(张曼丽)#^[1,2]Ding, Lili^[3];Wang, Xinrui^[2,4];Hou, Jie(侯洁)^[2]Li, Man^[2];Jiang, Yanfang^[2];He, Xiuting^[5];Cui, Meizi(崔美子)^[5]Hu, Feng^[1];Zhang, Xiuna^[1];Yang, Jingyuan^[1];Guo, Xiaohe^[6];Zhao, Huiying(赵慧颖)*^[2]Gao, Pujun(高普均)*^[4]
语种：

英文
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2018 年 57 卷 (181 - 189) ; APR
收录：
关键词：

Severe acute pancreatitis Monocyte Cytokine APACHE II score C-reactive protein
摘要：

Background: Despite the role of monocytes in the pathogenesis of severe acute pancreatitis (SAP), it remains unclear how different subtypes of monocytes regulate and contribute to this pathogenesis.
Methods: We examined the numbers of different subsets of monocytes by flow cytometry in 21 SAP, 15 mild acute pancreatitis (MAP) and 13 healthy controls (HC). The concentrations of plasma cytokines were assessed by cytometric bead array. Disease severity was evaluated based on the acute physiology and chronic health evaluation (APACHE) II score and plasma C-reactive proteins (CRP) levels.
Results: Compared with the numbers in MAP patients and HC, we observed that the numbers of CD14(+)CD163(-), CD14(+)CD163(-)MAC387(+), CD14(+) CD163(+)IL-12(+) Ml monocytes, and CD115(+), CD204(+), IL-10(+) M2 monocytes were significantly increased in SAP patients. In addition, these patients showed higher plasma levels of interleukin (IL)-12 and IL-10. Furthermore, the number of CD14(+) CD163(-), CD14(+)CD163(-)MAC387(+) Ml monocytes and the plasma IL-12 concentration showed a positive association with the CRP level, while the number of CD204(+), IL-10(+) M2 monocytes and the plasma IL-10 concentration showed a positive correlation with the APACHE II score. Importantly, the CD115(+) M2 subset displayed a positive correlation with both the CRP level and APACHE II score, and treatment of SAP significantly reduced the number of this subset.
Conclusions: The CD14(+)CD163(+)CD115(+) M2 monocyte count appears to be important factor in determining the severity and prognosis of SAP. Both the pro- and anti-inflammatory monocytes appear to participate in the pathogenesis of SAP.
推荐引用方式
GB/T 7714：

Zhang Manli,Ding Lili,Wang Xinrui, et al. Circulating CD14(+)CD163(+)CD115(+) M2 monocytes are associated with the severity of new onset severe acute pancreatitis in Chinese patients [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2018,57:181-189.
APA：

Zhang Manli,Ding Lili,Wang Xinrui,Hou Jie,&Gao Pujun.(2018).Circulating CD14(+)CD163(+)CD115(+) M2 monocytes are associated with the severity of new onset severe acute pancreatitis in Chinese patients .INTERNATIONAL IMMUNOPHARMACOLOGY,57:181-189.
MLA：

Zhang Manli, et al. "Circulating CD14(+)CD163(+)CD115(+) M2 monocytes are associated with the severity of new onset severe acute pancreatitis in Chinese patients" .INTERNATIONAL IMMUNOPHARMACOLOGY 57(2018):181-189.
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