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PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders 期刊论文

编号：

0ea92ff8-bff8-4659-b607-fd7a23a3c5b0
作者：

Wang, Dong#^[1,2,3]Chen, Jingyu^[1,2,3];Li, Rui^[1,2,3];Wu, Guolin^[4];Sun, Zimin^[4];Wang, Zhitao^[5];Zhai, Zhimin^[5];Fang, Fang^[1,2,3];Guo, Yugang^[1,2,3];Zhong, Yongjun^[1,2,3];Jiang, Ming^[1,2,3];Xu, Huan^[1,2,3];Chen, Minhua^[1,2,3];Shen, Guodong^[1,2,3];Sun, Jie^[1,2,3];Yan, Bailing(闫百灵)^[6]Yu, Chundong^[3];Tian, Zhigang^[1,2,3];Xiao, Weihua(肖卫华)*^[1,2,3]
语种：

英文
期刊：

JOURNAL OF CELL SCIENCE ISSN：0021-9533 2016 年 129 卷 11 期 (2261 - 2272) ; JUN 1
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关键词：

Drug resistance B-lymphoproliferative disorders NF-kappa B PAX5 RIP2
摘要：

Paired box protein 5 (PAX5) plays a lineage determination role in B-cell development. However, high expression of PAX5 has been also found in various malignant diseases, including B-lymphoproliferative disorders (B-LPDs), but its functions and mechanisms in these diseases are still unclear. Here, we show that PAX5 induces drug resistance through association and activation of receptor-interacting serine/threonine-protein kinase 2 (RIP2; also known as RIPK2), and subsequent activation of NF-kappa B signaling and anti-apoptosis gene expression in B-lymphoproliferative cells. Furthermore, PAX5 is able to interact with RIP1 and RIP3, modulating both RIP1-mediated TNFR and RIP2-mediated NOD1 and NOD2 pathways. Our findings describe a newfunction of PAX5 in regulating RIP1 and RIP2 activation, which is at least involved in chemotherapeutic drug resistance in B-LPDs.
推荐引用方式
GB/T 7714：

Wang Dong,Chen Jingyu,Li Rui, et al. PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders [J].JOURNAL OF CELL SCIENCE,2016,129(11):2261-2272.
APA：

Wang Dong,Chen Jingyu,Li Rui,Wu Guolin,&Xiao Weihua.(2016).PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders .JOURNAL OF CELL SCIENCE,129(11):2261-2272.
MLA：

Wang Dong, et al. "PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders" .JOURNAL OF CELL SCIENCE 129,11(2016):2261-2272.
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