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Genome-Wide Expression Profiling of the Response to Linezolid in Mycobacterium tuberculosis 期刊论文

编号：

1150b502-27ee-466f-93c1-0850e6633c25
作者：

Liang, Junchao#^[1]Tang, Xudong#^[2]Guo, Na(郭娜)#^[3]Zhang, Kaiyu(张凯宇)#^[4]Guo, Aizhen(郭爱珍)#^[5]Wu, Xiuping#^[1]Wang, Xuelin#^[1]Guan, Zhenhong#^[1]Liu, Lihui^[1];Shen, Fengge^[1];Xing, Mingxun^[1];Liu, Liqiang^[5];Li, Lei^[1];Yu, Lu*^[1]
语种：

英文
期刊：

CURRENT MICROBIOLOGY ISSN：0343-8651 2012 年 64 卷 6 期 (530 - 538) ; JUN
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关键词：

Antimycobacterial Linezoli Mycobacterium tuberculosis Microarray
摘要：

Tuberculosis (TB) is still one of the most common causes of death in the world. The emergence of multidrug-resistant and extensively drug-resistant (XDR-TB) Mycobacterium tuberculosis (M. tuberculosis) strains has increased the importance of searching for alternative targets to develop new antimycobacterial drugs. Linezolid, the first of oxazolidinones, is active in vitro against M. tuberculosis, but the response mechanisms of M. tuberculosis to linezolid are still poorly understood. To reveal the possible mechanism of action of linezolid against M. tuberculosis, commercial oligonucleotide microarrays were used to analyze the genome-wide transcriptional changes triggered by treatment with subinhibitory concentrations of linezolid. Quantitative real-time RT-PCR was performed for selected genes to verify the microarray results. A total of 729 genes were found to be differentially regulated by linezolid. Among these, 318 genes were upregulated, and 411 genes were downregulated. A number of important genes were significantly regulated that are involved in various pathways, such as protein synthesis, sulfite metabolism, and genes involved in the cell envelope and virulence. This genome-wide transcriptomics approach produced the first insights into the response of M. tuberculosis to a linezolid challenge.
推荐引用方式
GB/T 7714：

Liang Junchao,Tang Xudong,Guo Na, et al. Genome-Wide Expression Profiling of the Response to Linezolid in Mycobacterium tuberculosis [J].CURRENT MICROBIOLOGY,2012,64(6):530-538.
APA：

Liang Junchao,Tang Xudong,Guo Na,Zhang Kaiyu,&Yu Lu.(2012).Genome-Wide Expression Profiling of the Response to Linezolid in Mycobacterium tuberculosis .CURRENT MICROBIOLOGY,64(6):530-538.
MLA：

Liang Junchao, et al. "Genome-Wide Expression Profiling of the Response to Linezolid in Mycobacterium tuberculosis" .CURRENT MICROBIOLOGY 64,6(2012):530-538.
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