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Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway 期刊论文

编号：

12d37080-22c7-4fb1-adc1-e7294a3d3de0
作者：

Ci, Xinxin(慈鑫鑫)#^[1]Zhong, Weiting^[1];Ren, Hua(任华)^[1,3]Wen, Zhongmei(温中梅)^[1]Li, Dan(李丹)*^[1,2]Peng, Liping(彭丽萍)*^[1,2]
语种：

英文
期刊：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY ISSN：1018-2438 2015 年 167 卷 4 期 (280 - 290) ; 2015
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关键词：

Esculentoside A Asthma Heme oxygenase 1 Nuclear factor erythroid 2-related factor 2
摘要：

Background: The role of airway inflammation and inflammation-induced oxidative stress in the pathogenesis and progression of chronic inflammatory airway diseases has received increasing attention in recent years. We investigated the potential anti-inflammatory and antioxidative effects of esculentoside A (EsA), a saponin isolated from the Chinese herb Phytolacca esculenta, in comparison to dexamethasone, a potent corticosteroid, in a murine model of allergic asthma. Methods: EsA was added to cultures of A549 cells at different concentrations or for different lengths of time, and nuclear factor erythroid 2-related factor 2 (Nrf-2) translocation and heme oxygenase 1 expression were monitored. Mice treated with or without EsA and Nrf-2 siRNA were sensitized and challenged with ovalbumin (OVA) and developed airway inflammation and oxidative lung damage. The Th2-type cytokine levels and inflammatory cells in bronchoalveolar lavage fluid (BALF) and the serum immunoglobulin production and adhesion molecule expression in the lung tissues were measured. The activities of related anti-oxidases and glutathione were measured using assay kits. Results: EsA enhanced nuclear Nrf-2 translocation in both A549 cells and the lungs of OVA-challenged mice. Airway inflammation induced by OVA was reduced. Additionally, EsA increased nnRNA expression of antioxidant enzymes regulated by Nrf-2, leading to a reduction in Th2 cytokines and the expression of adhesion molecule mRNA in the BALF and lung tissues. Inhibition of Nrf-2 by siRNA abrogated the regulatory effects of EsA on inflammation and oxidant stress. Conclusions: This is the first study to illustrate that EsA acts as a novel Nrf-2 activator, which modulates the oxidative stress pathway to improve lung injury and ameliorate the development of airway inflammation. (C) 2015 S. Karger AG, Basel
推荐引用方式
GB/T 7714：

Ci Xinxin,Zhong Weiting,Ren Hua, et al. Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway [J].INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY,2015,167(4):280-290.
APA：

Ci Xinxin,Zhong Weiting,Ren Hua,Wen Zhongmei,&Peng Liping.(2015).Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway .INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY,167(4):280-290.
MLA：

Ci Xinxin, et al. "Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway" .INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 167,4(2015):280-290.
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