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Diagnostic Microdosing Approach to Study Gemcitabine Resistance 期刊论文

编号：

1b8e7852-ad18-4a79-85df-a0037c0030a0
作者：

Scharadin, Tiffany M.#^[1]Zhang, Hongyong^[1];Zimmermann, Maike^[1,3];Wang, Sisi(王思思)^[1,5]Malfatti, Michael A.^[2];Cimino, George D.^[3];Turteltaub, Kenneth^[2];White, Ralph de Vere^[4];Pan, Chongxian*^[1,3]Henderson, Paul T.*^[1,3]
语种：

English
期刊：

CHEMICAL RESEARCH IN TOXICOLOGY ISSN：0893-228X 2016 年 29 卷 11 期 (1843 - 1848) ; NOV
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摘要：

Gemcitabine metabolites cause the termination of DNA replication and induction of apoptosis. We determined whether subtherapeutic "microdoses" of gemcitabine are incorporated into DNA at levels that correlate to drug cytotoxicity. A pair of nearly isogenic bladder cancer cell lines differing in resistance to several chemotherapy drugs were treated with various concentrations of C-14-labeled gemcitabine for 4-24 h. Drug incorporation into DNA was determined by accelerator mass spectrometry. A mechanistic analysis determined that RRM2., a DNA synthesis protein and a known resistance factor, substantially mediated gemcitabine toxicity. These results support gemcitabine levels in DNA as a potential biomarker of drug cytotoxicity.
推荐引用方式
GB/T 7714：

Scharadin Tiffany M.,Zhang Hongyong,Zimmermann Maike, et al. Diagnostic Microdosing Approach to Study Gemcitabine Resistance [J].CHEMICAL RESEARCH IN TOXICOLOGY,2016,29(11):1843-1848.
APA：

Scharadin Tiffany M.,Zhang Hongyong,Zimmermann Maike,Wang Sisi,&Henderson Paul T..(2016).Diagnostic Microdosing Approach to Study Gemcitabine Resistance .CHEMICAL RESEARCH IN TOXICOLOGY,29(11):1843-1848.
MLA：

Scharadin Tiffany M., et al. "Diagnostic Microdosing Approach to Study Gemcitabine Resistance" .CHEMICAL RESEARCH IN TOXICOLOGY 29,11(2016):1843-1848.
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