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Clinical Features of Chromosome 6 Translocation in Male Carriers: A Report of 10 Cases and Review of the Literature  期刊论文  

  • 编号:
    1b9bf9b3-9407-4526-aeab-c94eb12bc0e8
  • 作者:
  • 语种:
    英文
  • 期刊:
    MEDICAL SCIENCE MONITOR ISSN:1643-3750 2018 年 24 卷 (4162 - 4168) ; JUN 18
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  • 摘要:

    Background: The literature indicates that chromosome 6 is involved in balanced translocation and is involved in reproductive failure. This aim of this study was to explore the clinical features of chromosome 6 translocation in male carriers.
    Material/Methods: We identified 10 patients who were carriers of chromosome 6 translocations and excluded the patients with varicocele, ejaculatory duct obstruction, and the other cause of infertility. The karyotype was analyzed using G-banding. A search for translocations on chromosome 6 involved in male infertility was performed using PubMed. We included cases of balanced chromosome 6 translocations involving adult men of fertile age and excluded those cases of live-born children, or those without breakpoints involving chromosome 6, or those with complex chromosomal translocations or chimeras.
    Results: All 10 patients underwent genetic counseling for infertility. Semen analysis showed that 1 case had azoospermia, while 9 cases exhibited normal semen criteria. The respective partners of the 9 cases with normal semen parameters had a tendency to miscarry: 3 experienced spontaneous and induced abortion because of abnormal embryos; 3 experienced 3 incidents of spontaneous abortion, 2 experienced double spontaneous abortion, and 1 experienced biochemical pregnancy on 3 occasions. Most of the chromosome 6 breakpoints in translocation carriers obtained by the PubMed search were associated with spontaneous abortion.
    Conclusions: Chromosome translocations involving chromosome 6 influence fertility status and lead to increased risk of miscarriage. Cytogenetic screening before opting for assisted reproductive technology and the breakpoints of chromosome 6 translocation should be considered for infertile male carriers.

  • 推荐引用方式
    GB/T 7714:
    Yang Xiao,Zhang Hongguo,Yu Yang, et al. Clinical Features of Chromosome 6 Translocation in Male Carriers: A Report of 10 Cases and Review of the Literature [J].MEDICAL SCIENCE MONITOR,2018,24:4162-4168.
  • APA:
    Yang Xiao,Zhang Hongguo,Yu Yang,Zhu Haibo,&Liu Ruizhi.(2018).Clinical Features of Chromosome 6 Translocation in Male Carriers: A Report of 10 Cases and Review of the Literature .MEDICAL SCIENCE MONITOR,24:4162-4168.
  • MLA:
    Yang Xiao, et al. "Clinical Features of Chromosome 6 Translocation in Male Carriers: A Report of 10 Cases and Review of the Literature" .MEDICAL SCIENCE MONITOR 24(2018):4162-4168.
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