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Low dose radiation prevents doxorubicin-induced cardiotoxicity 期刊论文

编号：

1cc2f440-ce2f-4420-9629-3da2409a7c1d
作者：

Jiang, Xin(姜新)#^[1]Hong, Yaqiong#^[1]Zhao, Di^[1];Meng, Xinxin^[1];Zhao, Lijing^[2];Du, Yanwei^[3];Wang, Zan^[4];Zheng, Yan^[5];Cai, Lu^[6,7,8];Jiang, Hongyu(姜宏宇)*^[1]
语种：

英文
期刊：

ONCOTARGET ISSN：1949-2553 2018 年 9 卷 1 期 (332 - 345) ; JAN 2
收录：
关键词：

low dose radiation hormesis adaptive response doxorubicin oxidative stress
摘要：

This study aimed to develop a novel and non-invasive approach, low-dose radiation (LDR, 75 mGy X-rays), to prevent doxorubicin (DOX)-induced cardiotoxicity. BALB/c mice were randomly divided into five groups, Control, LDR (a single exposure), Sham (treated same as LDR group except for irradiation), DOX (a single intraperitoneal injection of DOX at 7.5 mg/kg), and LDR/DOX (received LDR and 72 h later received DOX). Electrocardiogram analysis displayed several kinds of abnormal ECG profiles in DOX-treated mice, but less in LDR/DOX group. Cardiotoxicity indices included histopathological changes, oxidative stress markers, and measurements of mitochondrial membrane permeability. Pretreatment of DOX group with LDR reduced oxidative damages (reactive oxygen species formation, protein nitration, and lipid peroxidation) and increased the activities of antioxidants (superoxide dismutase and glutathione peroxidase) in the heart of LDR/DOX mice compared to DOX mice. Pretreatment of DOX-treated mice with LDR also decreased DOX-induced cardiac cell apoptosis (TUNEL staining and cleaved caspase-3) and mitochondrial apoptotic pathway (increased p53, Bax, and caspase-9 expression and decreased Bcl2 expression and..m dissipation). These results suggest that LDR could induce adaptation of the heart to DOX-induced toxicity. Cardiac protection by LDR may attribute to attenuate DOX-induced cell death via suppressing mitochondrial-dependent oxidative stress and apoptosis signaling.
推荐引用方式
GB/T 7714：

Jiang Xin,Hong Yaqiong,Zhao Di, et al. Low dose radiation prevents doxorubicin-induced cardiotoxicity [J].ONCOTARGET,2018,9(1):332-345.
APA：

Jiang Xin,Hong Yaqiong,Zhao Di,Meng Xinxin,&Jiang Hongyu.(2018).Low dose radiation prevents doxorubicin-induced cardiotoxicity .ONCOTARGET,9(1):332-345.
MLA：

Jiang Xin, et al. "Low dose radiation prevents doxorubicin-induced cardiotoxicity" .ONCOTARGET 9,1(2018):332-345.
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