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Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin 期刊论文

编号：

1d831a6e-7df6-4049-95ca-a13287487896
作者：

Lv, Mingyu#^[1,3]Wang, Jiawen#^[1]Zhu, Yingzi^[1];Wang, Xiaodan^[1];Zuo, Tao^[1];Liu, Donglai^[1,2];Zhang, Jingyao^[1];Wu, Jiaxin^[1];Zhang, Haihong^[1];Kong, Wei(孔维)*^[1,2]Yu, Xianghui(于湘晖)*^[1,2]
语种：

英文
期刊：

FEBS LETTERS ISSN：0014-5793 2013 年 587 卷 1 期 (37 - 43) ; JAN 4
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关键词：

HIV-1 Tetherin Vpu Overexpression
摘要：

Tetherin/BST-2/CD317 inhibits HIV-1 release from infected cells, but the viral Vpu protein efficiently antagonizes this antiviral activity through direct interaction between the transmembrane (TM) domains of each protein. Here, we demonstrated that overexpression of an inactive tetherin delGPI mutant, the TM domain of which could competitively block Vpu targeting of endogenous tetherin, potently inhibited HIV-1 release from human tetherin-positive cells in both transient and stable expression conditions. These results also suggest that heterologous dimerization occurred between the delGPI mutant and endogenous tetherin. These findings suggest that blocking the Vpu/tetherin interface may be a novel therapeutic approach against HIV-1 release.
Structured summary of protein interactions:
Vpu and Tetherin colocalize by fluorescence microscopy (View interaction)
Tetherin physically interacts with Vpu by anti tag coimmunoprecipitation (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
推荐引用方式
GB/T 7714：

Lv Mingyu,Wang Jiawen,Zhu Yingzi, et al. Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin [J].FEBS LETTERS,2013,587(1):37-43.
APA：

Lv Mingyu,Wang Jiawen,Zhu Yingzi,Wang Xiaodan,&Yu Xianghui.(2013).Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin .FEBS LETTERS,587(1):37-43.
MLA：

Lv Mingyu, et al. "Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin" .FEBS LETTERS 587,1(2013):37-43.
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