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Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice 期刊论文

编号：

208184d8-dafb-4773-bf5e-703670d300a1
作者：

Wang, Shudong(王树东)#^[1,2,3]Wang, Bowei#^[3,4]Wang, Yuehui(王越晖)*^[1,2]Tong, Qian(佟倩)^[1,2]Liu, Quan(刘全)^[1,2]Sun, Jian(孙健)^[1,2]Zheng, Yang(郑杨)*^[1,2]Cai, Lu^[3,5,6];
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ISSN：1422-0067 2017 年 18 卷 3 期 ; MAR
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关键词：

diabetic cardiomyopathy zinc supplement nuclear factor-erythroid 2-related factor 2 inflammation oxidative stress
摘要：

Diabetic cardiomyopathy (DCM) is highly prevalent in type 2 diabetes (T2DM) patients. Zinc is an important essential trace metal, whose deficiency is associated with various chronic ailments, including vascular diseases. We assessed T2DM B6. BKS(D)-Leprdb/J (db/db) mice fed for six months on a normal diet containing three zinc levels (deficient, adequate, and supplemented), to explore the role of zinc in DCM development and progression. Cardiac function, reflected by ejection fraction, was significantly decreased, along with increased left ventricle mass and heart weight to tibial length ratio, in db/db mice. As a molecular cardiac hypertrophy marker, atrial natriuretic peptide levels were also significantly increased. Cardiac dysfunction and hypertrophy were accompanied by significantly increased fibrotic (elevated collagen accumulation as well as transforming growth factor beta and connective tissue growth factor levels) and inflammatory (enhanced expression of tumor necrosis factor alpha, interleukin-1 beta, caspase recruitment domain family member 9, and B-cell lymphoma/leukemia 10, and activated p38 mitogen-activated protein kinase) responses in the heart. All these diabetic effects were exacerbated by zinc deficiency, and not affected by zinc supplementation, respectively. Mechanistically, oxidative stress and damage, mirrored by the accumulation of 3-nitrotyrosine and 4-hydroxy-2-nonenal, was significantly increased along with significantly decreased expression of Nrf2 and its downstream antioxidants (NQO-1 and catalase). This was also exacerbated by zinc deficiency in the db/db mouse heart. These results suggested that zinc deficiency promotes the development and progression of DCM in T2DM db/db mice. The exacerbated effects by zinc deficiency on the heart of db/db mice may be related to further suppression of Nrf2 expression and function.
推荐引用方式
GB/T 7714：

Wang Shudong,Wang Bowei,Wang Yuehui, et al. Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice [J].INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(3).
APA：

Wang Shudong,Wang Bowei,Wang Yuehui,Tong Qian,&Cai Lu.(2017).Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(3).
MLA：

Wang Shudong, et al. "Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice" .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18,3(2017).
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