首页 / 院系成果 / 成果详情页

Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells 期刊论文

编号：

2147a8b2-c917-4c2f-87ce-44826d9220ff
作者：

Zhao, Yinghua(赵英华)#^[1]Chu, Xiao#^[1]Chen, Jintong#^[1]Wang, Ying^[1];Gao, Sujun(高素君)^[2]Jiang, Yuxue^[1];Zhu, Xiaoqing^[2];Tan, Guangyun^[1];Zhao, Wenjie^[3,4];Yi, Huanfa(伊焕发)^[3,4]Xu, Honglin^[5];Ma, Xingzhe^[6];Lu, Yong*^[6]Yi, Qing*^[1,6]Wang, Siqing(王四清)*^[1]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2016 年 7 卷 ; AUG
收录：
摘要：

Dectin-1 signalling in dendritic cells (DCs) has an important role in triggering protective antifungal Th17 responses. However, whether dectin-1 directs DCs to prime antitumour Th9 cells remains unclear. Here, we show that DCs activated by dectin-1 agonists potently promote naive CD4(+) T cells to differentiate into Th9 cells. Abrogation of dectin-1 in DCs completely abolishes their Th9-polarizing capability in response to dectin-1 agonist curdlan. Notably, dectin-1 stimulation of DCs upregulates TNFSF15 and OX40L, which are essential for dectin-1-activated DC-induced Th9 cell priming. Mechanistically, dectin-1 activates Syk, Raf1 and NF-kappa B signalling pathways, resulting in increased p50 and RelB nuclear translocation and TNFSF15 and OX40L expression. Furthermore, immunization of tumour-bearing mice with dectin-1-activated DCs induces potent antitumour response that depends on Th9 cells and IL-9 induced by dectin-1-activated DCs in vivo. Our results identify dectin-1-activated DCs as a powerful inducer of Th9 cells and antitumour immunity and may have important clinical implications.
推荐引用方式
GB/T 7714：

Zhao Yinghua,Chu Xiao,Chen Jintong, et al. Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells [J].NATURE COMMUNICATIONS,2016,7.
APA：

Zhao Yinghua,Chu Xiao,Chen Jintong,Wang Ying,&Wang Siqing.(2016).Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells .NATURE COMMUNICATIONS,7.
MLA：

Zhao Yinghua, et al. "Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells" .NATURE COMMUNICATIONS 7(2016).
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：82  下载次数：0

分享到：

浏览次数：82

下载次数：0

打印次数：0