Prostate cancer is the most common cancer in men by way of diagnosis and a leading cause of cancer-related deaths. Early detection and intervention remains key to its optimum clinical management. This review provides the most updated information on the recent methods of prostate cancer screening, imaging and treatment modalities. Wherever possible, clinical trial data has been supplemented to provide a comprehensive overview of current prostate cancer research and development. Considering the recent success of immunotherapy in prostate cancer, we discuss cell, DNA and viruses based, as well as combinatorial immunotherapeutic strategies in detail. Furthermore, the potential of nanotechnology is increasingly being realized, especially in prostate cancer research, and we provide an overview of nanotechnology-based strategies, with special emphasis on nanotheranostics and multifunctional nanoconstructs. Understanding these recent developments is critical to the design of future therapeutic strategies to counter prostate cancer.
[1]Jilin Univ, Div 2, Dept Urol, Hosp 1, 3302 Jilin Rd, Changchun 130031, Jilin, Peoples R China.
[2]Jilin Univ, Dept Gynaecol & Obstet, Hosp 2, 218 Ziqiang Rd, Changchun 130041, Jilin, Peoples R China.
[3]Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48201 USA.
[4]Univ S Alabama, Mitchell Canc Inst, Oncol Sci, Mobile, AL 36604 USA.
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