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Hypoxia promotes the skewed differentiation of umbilical cord mesenchymal stem cells toward type II alveolar epithelial cells by regulating microRNA-145 期刊论文

编号：

2498270b-17c5-4d44-b419-c59de33f1fab
作者：

Li, Yang(李洋)#^[1]Shi, Xu(石旭)#^[2]Yang, Liming(杨立明)^[3]Mou, Yan^[4];Li, Yingbo^[2];Dang, Rongjing^[2];Li, Changyuan(李长远)*^[1]
语种：

英文
期刊：

GENE ISSN：0378-1119 2017 年 630 卷 (68 - 75) ; SEP 30
收录：
关键词：

Umbilical cord mesenchymal stem cells Type II alveolar epithelial cells Hypoxia Transforming growth factor-beta MicroRNA-145
摘要：

Mesenchymal stem cells (MSCs) are well recognized for their ability to differentiate into type II alveolar epithelial (ATII) cells in damaged lungs, which is critical for reepithelization and recovery in acute lung injury (ALI). However, the high level of transforming growth factor-beta (TGF-beta) commonly seen in injured lung tissues is also able to induce MSCs to differentiate into fibroblast-like cells. In this study, we found that hypoxia could promote umbilical cord mesenchymal stem cells (UCMSCs) differentiation into ATII cells rather than into fibroblast-like cells, and this effect was mainly mediated by microRNA-145 (miR-145), which could induce the inhibition of TGF-beta signaling by targeting TGF-beta receptor II (TGF beta RII). Clarifying the function of hypoxia in the fate determination of MSCs is important for improving stem cell-based therapies for ALI.
推荐引用方式
GB/T 7714：

Li Yang,Shi Xu,Yang Liming, et al. Hypoxia promotes the skewed differentiation of umbilical cord mesenchymal stem cells toward type II alveolar epithelial cells by regulating microRNA-145 [J].GENE,2017,630:68-75.
APA：

Li Yang,Shi Xu,Yang Liming,Mou Yan,&Li Changyuan.(2017).Hypoxia promotes the skewed differentiation of umbilical cord mesenchymal stem cells toward type II alveolar epithelial cells by regulating microRNA-145 .GENE,630:68-75.
MLA：

Li Yang, et al. "Hypoxia promotes the skewed differentiation of umbilical cord mesenchymal stem cells toward type II alveolar epithelial cells by regulating microRNA-145" .GENE 630(2017):68-75.
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