首页 / 院系成果 / 成果详情页

microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma 期刊论文

编号：

296b565c-0108-48af-b4f4-5f7b7315f9fe
作者：

Zhou, Changchun#^[2,3]Liu, Jibing#^[4]Li, Yang(李洋)#^[5]Liu, Li^[1,2];Zhang, Xiaojiao^[1,2];Ma, ChengYuan(马程远)^[6]Hua, ShuCheng(华树成)^[5]Yang, Ming(杨明)*^[1,2]Yuan, Qipeng(袁其朋)*^[1,2]
语种：

英文
期刊：

FEBS LETTERS ISSN：0014-5793 2011 年 585 卷 12 期 (1828 - 1834) ; JUN 23
收录：
关键词：

microRNA-1274a Sorafenib Hepatocellular cancer ADAM9
摘要：

Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with poor prognosis. Sorafenib, a multikinase inhibitor, has been widely used to treat patients with advanced HCC in clinic. We postulated that microRNAs (miRNA) might be involved in HCC target-chemotherapy with sorafenib. MiRNA profile of HepG2 was evaluated after cells were treated with vehicle or sorafenib and alterations in miRNA expression occurred with 14 miRNAs. MiR-1274a, which is up-regulated by sorafenib, could significantly repress expression of ADAM9, a protease that is involved in sorafenib target-therapy of HCC, in HCC cells. Taken together, our data emphasizes a new miRNA-based mechanism of sorafenib antitumor therapy. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zhou Changchun,Liu Jibing,Li Yang, et al. microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma [J].FEBS LETTERS,2011,585(12):1828-1834.
APA：

Zhou Changchun,Liu Jibing,Li Yang,Liu Li,&Yuan Qipeng.(2011).microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma .FEBS LETTERS,585(12):1828-1834.
MLA：

Zhou Changchun, et al. "microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma" .FEBS LETTERS 585,12(2011):1828-1834.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：5  下载次数：0

分享到：

浏览次数：5

下载次数：0

打印次数：0