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Stress-related upper gastrointestinal bleeding in adult neurocritical care patients: a Chinese multicenter, retrospective study 期刊论文

编号：

2a5f7fd3-b6bb-456f-845c-b27cc30a76f6
作者：

Wei, Junji(魏俊吉)#^[1,2]Jian, Rongcai^[3];Li, Lihong^[4];Kang, Dezhi^[5];Gao, Guodong^[4];You, Chao^[6];Zhang, Jianmin^[7];Gao, Liang^[8];Huang, Qibing^[9];Luo, Duanwu^[10];Zhao, Gang^[11];Zhang, Hongyi^[12];Wang, Shuo^[13];Wang, Renzhi(王任直)*^[1,2]
语种：

英文
期刊：

CURRENT MEDICAL RESEARCH AND OPINION ISSN：0300-7995 2019 年 35 卷 2 期 (181 - 187) ; FEB 1
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关键词：

Stress ulcer bleeding upper gastrointestinal bleeding neurocritical care Glasgow coma scale H2-receptor antagonists proton pump inhibitors
摘要：

Objective: China has limited data on stress-related gastrointestinal ulcers in patients admitted for neurosurgical care. This study evaluated the incidence of upper gastrointestinal bleeding (UGIB) and use of stress ulcer prophylaxis (SUP) in Chinese neurocritical care patients (Glasgow Coma Scale [GCS] score <= 10). Methods: This multicenter, retrospective study was performed from January 2015 to July 2015. Medical records of 1468 patients hospitalized during 2014 were reviewed. An estimated UGIB incidence rate of 4.4% was considered for precision of 1.3% for estimation of UGIB. The primary endpoint was evaluation of overall incidence of any overt UGIB in <= 14 days after cerebral lesion. Secondary endpoints included incidence of UGIB with or and without clinically significant complications, time to UGIB, associated risk factors and SUP used. Results: We analyzed 1416 patients (mean age: 53.7 +/- 14.00 years; males: 62.4%) with cerebral lesions. Overall incidence rate of UGIB <= 14 days was 12.9% (95% CI: 11.2%-14.7%), 0.76% with and 12.1% without significant clinical complications. Average time and duration of bleeding were 2.9 +/- 3.37 days and 4.2 +/- 8.4 days, respectively. The most significant risk factors for UGIB were mechanical ventilation for >48 hours (p < .0001), UGIB history (p = .0026) and use of anticoagulants (p < .0001). Acid-suppression drugs were administered for SUP in 79.0% of the patients, whereas 40.5% received hemostatic drugs. Conclusions: The rate of UGIB incidence was higher than the estimated rate in neurocritical care patients in China, suggesting the need for better management and treatment for stress-related mucosal disease in China. History of UGIB, mechanical ventilation and/or anticoagulants significantly affected UGIB.
推荐引用方式
GB/T 7714：

Wei Junji,Jian Rongcai,Li Lihong, et al. Stress-related upper gastrointestinal bleeding in adult neurocritical care patients: a Chinese multicenter, retrospective study [J].CURRENT MEDICAL RESEARCH AND OPINION,2019,35(2):181-187.
APA：

Wei Junji,Jian Rongcai,Li Lihong,Kang Dezhi,&Wang Renzhi.(2019).Stress-related upper gastrointestinal bleeding in adult neurocritical care patients: a Chinese multicenter, retrospective study .CURRENT MEDICAL RESEARCH AND OPINION,35(2):181-187.
MLA：

Wei Junji, et al. "Stress-related upper gastrointestinal bleeding in adult neurocritical care patients: a Chinese multicenter, retrospective study" .CURRENT MEDICAL RESEARCH AND OPINION 35,2(2019):181-187.
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