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Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-gamma 期刊论文

编号：

31fb7816-8688-421c-bdde-85468dee2ab9
作者：

Yan, Bailing(闫百灵)#^[1]Chen, Feng^[2];Xu, Lijun(许力军)*^[3]Wang, Yanshi^[4];Wang, Xuefu*^[4,5]
语种：

英文
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2017 年 7 卷 ; JUN 15
收录：
摘要：

Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the function of the IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a novel role of IL-28B in inducing type 1 immunity and protecting against ovalbumin (OVA)-induced allergic asthma in mice. IL-28B overexpression in wild-type mice promoted natural killer (NK) cell polarization in the lung, leading to the increased number of interferon (IFN)-gamma-producing NK1 cells as well as Th1 differentiation. Importantly, IL-28B overexpression had no protective effect on OVA-induced asthma in IFN-gamma-knockout (IFN-gamma-/-) mice. These results demonstrate that IL-28B ameliorates experimental allergic asthma via
推荐引用方式
GB/T 7714：

Yan Bailing,Chen Feng,Xu Lijun, et al. Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-gamma [J].SCIENTIFIC REPORTS,2017,7.
APA：

Yan Bailing,Chen Feng,Xu Lijun,Wang Yanshi,&Wang Xuefu.(2017).Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-gamma .SCIENTIFIC REPORTS,7.
MLA：

Yan Bailing, et al. "Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-gamma" .SCIENTIFIC REPORTS 7(2017).
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