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NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 Chinese patients with de novo acute myeloid leukemia 期刊论文

编号：

3238020d-4392-4f35-a629-b79be9774ad3
作者：

Su, Long(苏龙)#^[1]Gao, Su Jun(高素君)*^[1]Li, Wei(李薇)^[1]Tan, Ye Hui(谭业辉)^[1]Cui, Jiu Wei(崔久嵬)^[1]Hu, Rui Ping^[1];
语种：

英文
期刊：

HEMATOLOGY ISSN：1024-5332 2014 年 19 卷 6 期 (324 - 328) ; SEP
收录：
关键词：

Acute myeloid leukemia Molecular mutation Leukocyte Blast CD34
摘要：

Objectives: To explore NPM1, FLT3-ITD, CEBPA, and c-kit mutations in patients with acute myeloid leukemia (AML) from Chinese population.
Methods: In this study, we retrospectively analyzed the prevalence and clinical profile of NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 patients with de novo AML.
Results: The frequencies of NPM1, FLT3-ITD, c-kit, and CEBPA mutations were 15.4, 14.0, 7.64, and 25.6%, respectively. The occurrence rate of NPM1 mutations increased with age in patients younger than 60 years. NPM1, c-kit, and CEBPA mutations were all associated with French-American-British subtypes. Patients with NPM1 mutations and FLT3-ITD presented with higher peripheral white blood cell counts and marrow blast percentages.
Conclusion: Both this and previous studies may suggest low frequencies of NPM1 and FLT3-ITD mutations in AML patients from the Chinese population, and they may have a synergistic function in stimulating proliferation of leukemia cells.
推荐引用方式
GB/T 7714：

Su Long,Gao Su Jun,Li Wei, et al. NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 Chinese patients with de novo acute myeloid leukemia [J].HEMATOLOGY,2014,19(6):324-328.
APA：

Su Long,Gao Su Jun,Li Wei,Tan Ye Hui,&Hu Rui Ping.(2014).NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 Chinese patients with de novo acute myeloid leukemia .HEMATOLOGY,19(6):324-328.
MLA：

Su Long, et al. "NPM1, FLT3-ITD, CEBPA, and c-kit mutations in 312 Chinese patients with de novo acute myeloid leukemia" .HEMATOLOGY 19,6(2014):324-328.
入库时间：

5/20/2019 5:38:00 PM
更新时间：

5/20/2019 5:38:00 PM
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