The purpose of this study was to compare the relative efficacy and safety of different antibiotic drugs and recommend superior regimens in the treatment of bronchitis. With respect to the antibiotic comparisons against quinolones in terms of intention-to-treat patients, we concluded that quinolones had advantages over placebo, beta-lactams, sulfonamides, and double beta-lactams. Concerning treatment methods for clinically evaluable patients, quinolones demonstrated better performance than beta-lactams and sulfonamides. The secondary effects of macrolides, quinolones, and double beta-lactams were significantly more adverse than beta-lactams with odds ratios (ORs) of 1.5 (95% credible interval [CrI] = 1.1-2.0), 1.7 (95% CrI = 1.2-2.3), and 2.7 (95% CrI = 1.8-4.1), respectively. Significant differences in the prevalence of diarrhea as a secondary effect were only identified among the comparisons of double beta-lactams against beta-lactams and macrolides (OR = 5.0, 95% CrI = 2.1-12.0; OR = 3.0, 95% CrI = 1.7-5.4, respectively). Quinolones can be recommended as the superior treatment for bronchitis, in accordance with our cluster analysis with surface under the cumulative ranking curve. The primary outcomes of network meta-analysis indicated that quinolones showed the best performance among the 8 treatments studied, although beta-lactams showed the lowest risk of adverse side effects. Quinolones are recommended as the primary treatment option for bronchitis patients, having taking into account the success rates and safety profiles of the eight drugs studied here.
[1]Jilin Univ, Hosp 1, Pediat Rheumatol Immunol & Allergy, Changchun, Jilin, Peoples R China.
[2]Jilin Univ, Hosp 1, Dept Anesthesiol, Changchun, Jilin, Peoples R China.
[3]Xinjiang Med Univ, Affiliated Hosp 1, Dept Oncol, Urumqi, Peoples R China.
[4]Jilin Univ, Hosp 1, Dept Resp, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
(8.0+极速模式)