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Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide 期刊论文

编号：

35981f1d-9c9c-4346-965f-6afc3d373477
作者：

Ju, Weina(鞠维娜)#^[1,7]Li, Qi#^[8]Allette, Yohance M.^[2];Ripsch, Matthew S.^[2];White, Fletcher A.^[1,2,4,5];Khanna, Rajesh*^[1,3,4,5,6]
语种：

英文
期刊：

JOURNAL OF NEUROCHEMISTRY ISSN：0022-3042 2013 年 124 卷 6 期 (869 - 879) ; MAR
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关键词：

calcium imaging CaV2.2 CRMP2 neuropathic pain peptide inhibitor polyarginine motif
摘要：

The N-type voltage-gated calcium channel (CaV2.2) is a clinically endorsed target in chronic pain treatments. As directly targeting the channel can lead to multiple adverse side effects, targeting modulators of CaV2.2 may prove better. We previously identified ST1-104, a short peptide from the collapsin response mediator protein 2 (CRMP2), which disrupted the CaV2.2CRMP2 interaction and suppressed a model of HIV-related neuropathy induced by anti-retroviral therapy but not traumatic neuropathy. Here, we report ST2-104 a peptide wherein the cell-penetrating TAT motif has been supplanted with a homopolyarginine motif, which dose-dependently inhibits the CaV2.2CRMP2 interaction and inhibits depolarization-evoked Ca2+ influx in sensory neurons. Ca2+ influx via activation of vanilloid receptors is not affected by either peptide. Systemic administration of ST2-104 does not affect thermal or tactile nociceptive behavioral changes. Importantly, ST2-104 transiently reduces persistent mechanical hypersensitivity induced by systemic administration of the anti-retroviral drug 2,3-dideoxycytidine (ddC) and following tibial nerve injury (TNI). Possible mechanistic explanations for the broader efficacy of ST2-104 are discussed.
推荐引用方式
GB/T 7714：

Ju Weina,Li Qi,Allette Yohance M., et al. Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide [J].JOURNAL OF NEUROCHEMISTRY,2013,124(6):869-879.
APA：

Ju Weina,Li Qi,Allette Yohance M.,Ripsch Matthew S.,&Khanna Rajesh.(2013).Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide .JOURNAL OF NEUROCHEMISTRY,124(6):869-879.
MLA：

Ju Weina, et al. "Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide" .JOURNAL OF NEUROCHEMISTRY 124,6(2013):869-879.
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