Cerebral autoregulation is defined as the mechanism by which constant cerebral blood flow is maintained despite changes of arterial blood pressure, and arterial blood pressure represents the principle aspect of cerebral autoregulation. The impairment of cerebral autoregulation is reported to be involved in several diseases. However, the concept, mechanisms, and pathological dysfunction of cerebral autoregulation are beyond full comprehension. Nitric oxide control and sympathetic control are main contributors to cerebral autoregulation. Although impaired cerebral autoregulation after nitric oxide inhibition or sympathetic ganglia blockade is reported, managing the inhibition or blockade can have negative consequences and needs further exploration. Additionally, impaired cerebral autoregulation following subarachnoid hemorrhage and traumatic brain injury has been proven by several descriptive studies, although without corresponding explanations. As the most important mechanisms of cerebral autoregulation, the changes of nitric oxide and sympathetic stimulation play significant roles in these insults. Therefore, the in-depth researches of nitric oxide and sympathetic nerve in cerebral autoregulation may help to develop new therapeutic targets.
[1]Jilin Univ, Dept Neurol, Neurosci Ctr, Hosp 1, Xinmin St 71, Changchun 130021, Peoples R China.
[2]Zhejiang Univ, Sch Med, Dept Neurosurg, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
[3]Zhejiang Univ, Sch Med, Dept Neurol, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
[4]Jilin Univ, Coll Automobile Engn, Changchun, Peoples R China.
[5]Chinese Acad Sci, Shenzhen Inst Adv Technol, Xueyuan Ave, Shenzhen, Peoples R China.
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