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Biological and biomechanical analysis of two types of mesenchymal stem cells for intervention in chemotherapy-induced ovarian dysfunction 期刊论文

编号：

38b1d48a-0088-464e-9131-34312e217641
作者：

Pan, Yuan(潘袁)#^[1]Zhang, Liqun^[1];Zhang, Xinyue(张馨月)^[1]Hu, Cong(扈聪)^[1]Liu, Ruizhi(刘睿智)*^[1]
语种：

英文
期刊：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS ISSN：0932-0067 2017 年 295 卷 1 期 (247 - 252) ; JAN
收录：
关键词：

Rat Ovary Chemotherapy injury UC-MSCs H-AMSCs Intervention Function Mechanical properties
摘要：

The study aim was to investigate the biological and biomechanical features of a chemotherapy-induced ovarian dysfunction (CIOD) rat model after intervention with human umbilical cord mesenchymal stem cells (UC-MSCs) and human amniotic mesenchymal stem cells (h-AMSCs), thus providing a biological and biomechanical research basis for clinical treatment.
The serum levels of estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and vascular endothelial growth factor (VEGF) in the rat CIOD models were evaluated on the 14th, 30th, 60th, and 90th day of intervention with h-AMSCs and UC-MSCs. In addition, the ovaries in each group were sampled on the 14th and 90th day of intervention for tissue morphology and tensile testing.
The serum levels of E2, LH, and VEGF in the h-AMSC and UC-MSC groups were greater than in the model group, but the serum FSH level was less than in the model group, and the differences were significant (P < 0.05); the maximum tensile stress and maximum strain in h-AMSC and UC-MSC groups were significantly greater than in the model group (P < 0.05).
UC-MSC and h-AMSC intervention restored damaged ovarian morphology, elasticity, and toughness to a certain extent, and ovarian function showed some recovery.
推荐引用方式
GB/T 7714：

Pan Yuan,Zhang Liqun,Zhang Xinyue, et al. Biological and biomechanical analysis of two types of mesenchymal stem cells for intervention in chemotherapy-induced ovarian dysfunction [J].ARCHIVES OF GYNECOLOGY AND OBSTETRICS,2017,295(1):247-252.
APA：

Pan Yuan,Zhang Liqun,Zhang Xinyue,Hu Cong,&Liu Ruizhi.(2017).Biological and biomechanical analysis of two types of mesenchymal stem cells for intervention in chemotherapy-induced ovarian dysfunction .ARCHIVES OF GYNECOLOGY AND OBSTETRICS,295(1):247-252.
MLA：

Pan Yuan, et al. "Biological and biomechanical analysis of two types of mesenchymal stem cells for intervention in chemotherapy-induced ovarian dysfunction" .ARCHIVES OF GYNECOLOGY AND OBSTETRICS 295,1(2017):247-252.
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