Purpose of investigation: To characterize histopathological status, high-risk human papillomavirus (hr-HPV) infection status, and associated risk factors in patients with atypical squamous cells of undetermined significance (ASCUS). Materials and Methods: Cervical biopsies obtained from 130 ASCUS patients were subjected to histopathological examination and hr-HPV testing. Associations between advanced lesions and hr-HPV load or age were analyzed, and the confounding factors for high-grade cervical lesions were identified. Results: Cervical biopsies from ASCUS patients had a wide range of pathological states, ranging from normal to invasive cervical carcinoma. High-risk ITV infection was significantly associated with advanced cervical lesions in ASCUS patients; hr-HPV infection and the number of gestations were risk factors for developing advanced cervical disease. Conclusions: A significant portion of ASCUS patients harbor advanced cervical lesions. The number of gestations and hr-HPV infection can increase the risk of developing advanced cervical lesions in ASCUS patients.
[1]Jilin Univ, Hosp 1, Dept Gynecol, Changchun 130021, Peoples R China.
[2]Maternal & Children Healths Hosp, Dept Obstet, Weifang, Peoples R China.
[3]Jilin Univ, China Japan Union Hosp, Dept Orthoped, Changchun 130021, Peoples R China.
(8.0+极速模式)