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Clinical significance of serum-terminal pro-B-type natriuretic peptide in patients with acute cerebral stroke 期刊论文

编号：

39c5ba40-51fa-45bc-84dd-0dffb6deea42
作者：

Yang, Qi(杨琦)#^[1]Li, Chang(李畅)#^[2]Wang, Le(王乐)^[3]Wei, Bo(韦博)*^[4]
语种：

英文
期刊：

PANMINERVA MEDICA ISSN：0031-0808 2018 年 60 卷 4 期 (145 - 150) ; DEC
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关键词：

pro-brain natriuretic peptide (1-76) Stroke Glasgow Coma Scale Prognosis
摘要：

BACKGROUND: To investigate the relationships of the changes of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) level with the severity of the disease (infarct size, amount of bleeding, National Institutes of Health Stroke Scale [NIHSS] Score and Glasgow Coma Scale [GCS] Score) and prognosis in acute cerebral stroke patients.
METHODS: Acute cerebral stroke patients admitted to our hospital from August 2015 to August 2017 were enrolled in this study. The NT-proBNP level, infarct size, amount of bleeding, NIHSS Score, GCS Score and Modified Rankin Scale (MRS) Score at 3 months after onset in patients in cerebral infarction group and cerebral hemorrhage group were observed at 24 h, (5 +/- 2) d and (12 +/- 2) d. The correlations of NT-proBNP level with the severity of the disease and MRS Score at 3 months after onset were also analyzed.
RESULTS: The serum NT-proBNP levels in patients in infarction group and hemorrhage group were significantly higher than those in control group at 24 h and (5 +/- 2) d after onset (P<0.01). The serum NT-proBNP level at 24 h after onset in hemorrhage group had statistically significant difference from that at (5 +/- 2) d in the same group, and those at 24 h and (5 +/- 2) d after onset in infarction group and hemorrhage group had statistically significant difference from those at (12 +/- 2) d in the same group (P<0.01). There were significant differences in NT-proBNP levels among subgroups with different NIHSS scores (P<0.01). GCS Score was significantly correlated with NT-proBNP level (P<0.01). The higher the level of serum NT-proBNP, the higher the patient's MRS Score at 3 months after onset was.
CONCLUSIONS: Serum NT-proBNP level can be used as a serum biological indicator to evaluate the severity and prognosis of cerebral stroke patients.
推荐引用方式
GB/T 7714：

Yang Qi,Li Chang,Wang Le, et al. Clinical significance of serum-terminal pro-B-type natriuretic peptide in patients with acute cerebral stroke [J].PANMINERVA MEDICA,2018,60(4):145-150.
APA：

Yang Qi,Li Chang,Wang Le,Wei Bo.(2018).Clinical significance of serum-terminal pro-B-type natriuretic peptide in patients with acute cerebral stroke .PANMINERVA MEDICA,60(4):145-150.
MLA：

Yang Qi, et al. "Clinical significance of serum-terminal pro-B-type natriuretic peptide in patients with acute cerebral stroke" .PANMINERVA MEDICA 60,4(2018):145-150.
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