Capsaicin (CAP) is the major pungent component of chili pepper and is being evaluated for use against numerous types of tumors. Although CAP is indicated to target multiple signaling pathways, exact mechanisms of how it disturb cancer cell metablism remain obscure. Recent studies revealed Sirtuin 1 (SIRT1) serves as a potential target of CAP in cancer cells, indicating a direct regulation of cancer cell histone acetylation by capsaicin. The present study evaluated the effect of CAP on gastric cancer (GC) cell lines to understand the mechanism of cell growth inhibition. The results showed that CAP could significantly suppress cell growth, while altering histone acetylation in GC cell lines. Further studies found that hMOF, a major histone acetyltranferase for H4K16, is central to CAP-induced epigenetic changes. Reduced hMOF activity was detected in GC tissues, which could be restored by CAP both in vivo and in vitro. These findings revealed an important role of hMOF-mediated histone acetylation in CAP-directed anti-cancer processes, and suggested CAP as a potential drug for use in gastric cancer prevention and therapy.
[1]Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China.
[2]Changchun Univ Tradit Chinese Med, Sch Pharm, Changchun, Jilin, Peoples R China.
[3]Jilin Univ, Bethune Hosp 1, Bethune Inst Epigenet Med, Changchun, Jilin, Peoples R China.
[4]Jilin Univ, Bethune Hosp 1, Dept Gastrointestinal Surg, Changchun, Jilin, Peoples R China.
[5]Natl Engn Lab AIDS Vaccine, Changchun, Peoples R China.
[6]Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun, Jilin, Peoples R China.
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