Ordered mesoporous titania supported copper hydroxide was used as catalysts in heterogeneous oxidative homocoupling of alkynes(Glaser reaction). The results showed high catalytic performance. Highly dispersed copper hydroxide was regarded as the active site and mesoporous structure of TiO2 benefit the high dispersion of active sites as well as the diffusion of the reactants and products in the reactions. 1,3-Dyne derivative, the products of Glaser reaction, is an important class of compounds in chemistry and materials science. Thus, Cu(OH)(2)/TiO2 is of great importance in the industrial application.