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ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese 期刊论文

编号：

3ef4b135-a2f4-48c2-bd9b-b7354c50d603
作者：

Sun, Chengjun#^[1]Wei, Haiyan#^[2]Chen, Xiuli#^[3]Zhao, Zhuhui^[1];Du, Hongwei(杜红伟)^[4]Song, Wenhui^[5];Yang, Yu^[6];Zhang, Miaoying^[1];Lu, Wei(陆炜)^[1]Pei, Zhou^[1];Xi, Li^[1];Yang, Jian^[7];Zhi, Dijing(支涤静)^[1]Cheng, Ruoqian(程若倩)*^[1]Luo, Feihong(罗飞宏)^[1]
语种：

英文
期刊：

META GENE ISSN：2214-5400 2016 年 9 卷 (120 - 123) ; SEP
收录：
关键词：

Type 1 diabetes Genetic association Single nucleotide polymorphism ERBB3
摘要：

Type 1 diabetes (T1D) is an autoimmune disease that has strong contribution of genetic factors to its etiology. We aimed to assess the genetic association between non-HLA genes and T1D in a Chinese case-control cohort recruited from multiple centers consisting of 364 patients with T1D and 719 unrelated healthy children. We genotyped 55 single nucleotide polymorphisms (SNP) markers located in 16 non-HLA genes (VTCN1, PTPN22, CTLA4, SUMO4, CD274, IL2RA, INS, DHCR7, ERBB3, VDR, CYP27B1, CD69, CD276, PTPN2, UBASH3A, and IL2RB) using SNaPshot multiple single-base extension methods. After multivariate analysis and correction for multiple comparisons, we identified the SNP rs2292239 in ERBB3 gene were significantly associated with T1D. The frequency of the major G allele was significantly decreased in patients with T1D (68.8% in T1D vs 77.3% in controls, OR 0.65, 95% CI 0.53-0.79, P = 0.02), and the minor allele T was associated with an increased risk of T1D (OR 1.55, 95% CI 1.26-1.90, P = 0.02). Our haplotype analysis confirmed that rs2292239 was the primary T1D association locus in our current investigation. These results indicated that the ERBB3-rs2292239 was the primary T1D association locus among the investigated 55 SNPs in 16 non-HLA genes in Chinese Han population. (C) 2016 The Authors. Published by Elsevier B.V.
推荐引用方式
GB/T 7714：

Sun Chengjun,Wei Haiyan,Chen Xiuli, et al. ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese [J].META GENE,2016,9:120-123.
APA：

Sun Chengjun,Wei Haiyan,Chen Xiuli,Zhao Zhuhui,&Luo Feihong.(2016).ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese .META GENE,9:120-123.
MLA：

Sun Chengjun, et al. "ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese" .META GENE 9(2016):120-123.
入库时间：

12/16/2019 3:17:20 PM
更新时间：

12/16/2019 3:17:20 PM
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