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Protection of Micro-Gravity Induced Bone Loss by Intermittent Mechanical Vibration 期刊论文

编号：

41f3c23f-5237-4b64-8d60-44e7d6bb87f5
作者：

Huang, Xu#^[1]Gu, Guishan(谷贵山)^[2]Ma, Renshi(马韧石)^[3]Sun, Di(孙迪)^[4]Tan, Lei(谭磊)^[5]Zhao, Bin^[5];Yu, Jing^[5];Zhu, Dong(朱东)*^[5]Zhang, Xizheng^[6];
语种：

英文
期刊：

JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING ISSN：2157-9083 2015 年 5 卷 10 期 (766 - 773) ; OCT
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关键词：

Bone Loss Recovery Weightlessness Mechanical Vibration Biomechanics Histomorphometry
摘要：

We aimed to investigate a type of more efficacious mechanical vibration to protect against early bone loss in rodents after hindlimb suspension. Forty-nine adult male Wistar rodents were randomly assigned to 7 groups, 7 animals/group, i.e., baseline control (BCL, no treatment), 24 h disuse via hindlimb suspension per day(20) (Dis), disused and subjected to daily loading at 35 Hz and 0.25 g for 15 min each day (DL),(9,10) disused and interrupted by mechanical vibration of 35 Hz and 0.25 g for 15 min every other day (MS1), disused and interrupted by stimuli for 15 min for three consecutive days on every other three days (MS3), disused and interrupted by stimuli for 15 min for five consecutive days on every other five days (MS5), and disused and interrupted by mechanical vibration for 15 min for 1 week on every other week (MS7). All animals were subjected to hindlimb suspension during the 8-week protocol except the BCL. Potential nerve transduction velocity of right sciatic nerve was tested in vivo, and the three-point test and histomorphology examination were performed in the tibia after rodents sacrifice. Improvements in failure load, potential nerve transduction velocity and Young's modulus and deflection were monitored, with the most significant improvement in MS7 group, comparing that in group with daily loading and (p < 0.05). The MS7 group also showed the largest fluorescence area or line spacing, thickest trabeculae and trabecular separation. Our results indicated that daily mechanical vibration, with or without a recovery period, could protect animals from microgravity induced tissue damage, including osteopenia and delayed nerve potential transduction velocity, while vibration with a recovery period provides best protection.
推荐引用方式
GB/T 7714：

Huang Xu,Gu Guishan,Ma Renshi, et al. Protection of Micro-Gravity Induced Bone Loss by Intermittent Mechanical Vibration [J].JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,2015,5(10):766-773.
APA：

Huang Xu,Gu Guishan,Ma Renshi,Sun Di,&Zhang Xizheng.(2015).Protection of Micro-Gravity Induced Bone Loss by Intermittent Mechanical Vibration .JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,5(10):766-773.
MLA：

Huang Xu, et al. "Protection of Micro-Gravity Induced Bone Loss by Intermittent Mechanical Vibration" .JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 5,10(2015):766-773.

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