Objective We present a new technique of 3-dimensional computed tomography-guided interstitial (IS) brachytherapy (BT) for locally advanced cervical cancer, offering a more advantageous clinical treatment approach.
Materials/Methods Interstitial BT was performed using an applicator combining uterine tandem and metal needles; needles were inserted freehand under real-time 3-dimensional computed tomography guidance. Twenty-eight patients with bulky tumors and/or parametrial extension (tumor size > 5 cm) after external beam radiotherapy received IS BT. Dosimetric outcomes of the IS BT including the total dose (external beam radiotherapy and high dose-rate BT) D90 for the high-risk clinical target volume (HR-CTV) and D2cc for the organs at risk (OARs) were investigated and compared with a former patient group consisting of 30 individuals who received the conventional intracavitary (IC) BT.
Results The mean D90 values for HR-CTV in the IC BT and IS BT groups were 76.9 5.7 and 88.1 +/- 3.3 Gy, respectively. Moreover, 85.7% of the patients received D90 for HR-CTV of 87 Gy or greater in the IS BT group, and only 6.7% of the patients received D90 for HR-CTV of 87 Gy or greater in the IC BT group. The D2cc for the bladder, rectum, and sigmoid were 84.7 +/- 6.8, 69.2 +/- 4.2, and 67.8 +/- 4.5 Gy in the IC BT group and 81.8 +/- 6.5, 66.8 +/- 4.0, and 64.8 +/- 4.1 Gy in the IS BT group. The mean number of needles was 6.9 +/- 1.4, with a mean depth of 2.9 +/- 0.9 mm for each IS BT. Interstitial BT was associated with only minor complications.
Conclusions The IS BT technique resulted in better dose-volume histogram parameters for large volume tumors (>5 cm) compared with the conventional IC BT and acceptable risk of acute complications in locally advanced cervical cancer and is clinically feasible.
[1]Jilin Univ, Affiliated Hosp 2, Dept Radiat Oncol, 218 Zi Qiang St, Changchun 130041, Peoples R China.
[2]Jilin Univ, Affiliated Hosp 1, Ctr Canc, Changchun, Peoples R China.
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