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Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities aganist Lipopolysaccharide and D-Galactosamine-Induced Fulminant Hepatic Failure 期刊论文

编号：

427b44d2-660f-4ee5-b678-8c4c74002352
作者：

Lv, Hongming#^[1,2]Qi, Zhimin#^[1,2]Wang, Sisi(王思思)^[1]Feng, Haihua^[1,2];Deng, Xuming^[1,2];Ci, Xinxin(慈鑫鑫)*^[1]
语种：

英文
期刊：

FRONTIERS IN IMMUNOLOGY ISSN：1664-3224 2017 年 8 卷 ; JUL 7
收录：
关键词：

asiatic acid inflammation oxidative stress fulminant hepatic failure AMPK/Nrf2 PDCD4
摘要：

Inflammation and oxidative stress are essential for the pathogenesis of fulminant hepatic failure (FHF). Asiatic acid (AA), which is a pentacyclic triterpene that widely occurs in various vegetables and fruits, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the protective effects of AA against lipopolysaccharide (LPS) and D-galactosamine (GalN)-induced FHF and the underlying molecular mechanisms. Our findings suggested that AA treatment effectively protected against LPS/D-GalN-induced FHF by lessening the lethality; decreasing the alanine transaminase and aspartate aminotransferase levels, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha production, malondialdehyde formation, myeloperoxidase level and reactive oxygen species generation (i.e., H2O2, NO, and O-2(-)), and increasing the glutathione and superoxide dismutase contents. Moreover, AA treatment significantly inhibited mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappa B) signaling pathway activation via the partial induction of programmed cell death 4 (PDCD4) protein expressions, which are involved in inflammatory responses. Furthermore, AA treatment dramatically induced the expression of the glutamate-cysteine ligase modifier subunit, the glutamate-cysteine ligase catalytic subunit, heme oxygenase-1, and NAD (P) H: quinoneoxidoreductase 1 (NQO1), which are largely dependent on activation of the nuclear factor-erythroid 2-related factor 2 (Nrf2) through the induction of AMP-activated protein kinase (AMPK) and glycogen synthase kinase-3 beta (GSK3 beta) phosphorylation. Accordingly, AA exhibited protective roles against LPS/D-GalN-induced FHF by inhibiting oxidative stress and inflammation. The underlying mechanism may be associated with the inhibition of MAPK and NF-kappa B activation via the partial induction of PDCD4 and upregulation of Nrf2 in an AMPK/GSK3 beta pathway activation-dependent manner.
推荐引用方式
GB/T 7714：

Lv Hongming,Qi Zhimin,Wang Sisi, et al. Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities aganist Lipopolysaccharide and D-Galactosamine-Induced Fulminant Hepatic Failure [J].FRONTIERS IN IMMUNOLOGY,2017,8.
APA：

Lv Hongming,Qi Zhimin,Wang Sisi,Feng Haihua,&Ci Xinxin.(2017).Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities aganist Lipopolysaccharide and D-Galactosamine-Induced Fulminant Hepatic Failure .FRONTIERS IN IMMUNOLOGY,8.
MLA：

Lv Hongming, et al. "Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities aganist Lipopolysaccharide and D-Galactosamine-Induced Fulminant Hepatic Failure" .FRONTIERS IN IMMUNOLOGY 8(2017).
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