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Murine double minute 2 siRNA and wild-type p53 gene therapy enhances sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro and in vivo 期刊论文

编号：

434e24e6-c85b-4f16-9249-ce1d3e6273b6
作者：

Gu, Junlian#^[1]Tang, Yufeng#^[2]Liu, Yanan^[1];Guo, Hua^[1];Wang, Yue^[1];Cai, Lu^[3,4,5];Li, Yang*^[1]Wang, Bo(王波)*^[6]
语种：

英文
期刊：

CANCER LETTERS ISSN：0304-3835 2014 年 343 卷 2 期 (200 - 209) ; FEB 28
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关键词：

SKOV3/DDP Drug resistance Cisplatin P53 Si-mdm2
摘要：

SKOV3/DDP cells urgently require an efficient therapy to improve drug resistance. Here we show a critical role for cisplatin combined with gene therapy, using transfection of a p53 gene/MDM2-siRNA plasmid, in improving cisplatin sensitivity of SKOV3/DDP cells with a strong inhibition of tumor cell growth in vitro and in vivo. The effects may be associated with enhancement of intracellular platinum accumulation via decreased MDR1/P-gp and improvement of apoptotic resistance via increased P53, PUMA and NOXA expression. The combined therapy may efficiently inhibit cell invasion and migration via deceased HIFI, VEGF, MMP-9 and MMP-2 to suppress malignant progression. These results indicate that cisplatin chemotherapy combined with targeting the MDM2/p53 axis is an attractive strategy to treat SKOV3/DDP cancer. Crown Copyright (c) 2013 Published by Elsevier Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Gu Junlian,Tang Yufeng,Liu Yanan, et al. Murine double minute 2 siRNA and wild-type p53 gene therapy enhances sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro and in vivo [J].CANCER LETTERS,2014,343(2):200-209.
APA：

Gu Junlian,Tang Yufeng,Liu Yanan,Guo Hua,&Wang Bo.(2014).Murine double minute 2 siRNA and wild-type p53 gene therapy enhances sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro and in vivo .CANCER LETTERS,343(2):200-209.
MLA：

Gu Junlian, et al. "Murine double minute 2 siRNA and wild-type p53 gene therapy enhances sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro and in vivo" .CANCER LETTERS 343,2(2014):200-209.
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