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Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report 期刊论文

编号：

486618d6-b082-47d9-88f9-a17d07ecae36
作者：

Liu, Guangming(刘广明)#^[1,2]Lu, Xianglan^[2];Kim, Young Mi^[2];Wang, Xianfu^[2];Li, Shibo*^[2]Liu, Yuanyuan(刘媛媛)*^[1]
语种：

English
期刊：

MEDICINE ISSN：0025-7974 2018 年 97 卷 21 期 ; MAY
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关键词：

FISH infant ALL MLL-AFF1 t (4 11 11) t (9 21)
摘要：

Rationale:Three-way translocations occasionally occur in MLL-AFF1 fusion and other fusion gene. However, the complex chromosomal rearrangements in the study were the first report.Patient concerns:We present novel cryptic and complex chromosomal rearrangements [der (21) t (9; 21) (p13; p11.2)] in an infant patient with relapsed acute lymphoblastic leukemia (ALL).Diagnoses:The diagnosis was based on morphologic, cytochemical, and immunophenotypic criteria proposed by the French-American-British Committee, and karyotype, fluorescence in situ hybridization, array comparative genomic hybridization.Interventions:The patient was given chemotherapy with standard protocol for ALL.Outcomes:The patient had unfavorable prognostic outcome based on the cytogenetic and molecular cytogenetic markers. After short remission, the patient relapsed.Lessons:MLL-AFF1, resulting from t(4;11)(q21;q23), is regarded as the hallmark of infant t(4;11) pre-B/mixed B-ALL. It is associated with a dismal prognosis and the multiple-way translocation involving chromosomes 4, 11 and 11 may function as an enhancer.
推荐引用方式
GB/T 7714：

Liu Guangming,Lu Xianglan,Kim Young Mi, et al. Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report [J].MEDICINE,2018,97(21).
APA：

Liu Guangming,Lu Xianglan,Kim Young Mi,Wang Xianfu,&Liu Yuanyuan.(2018).Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report .MEDICINE,97(21).
MLA：

Liu Guangming, et al. "Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report" .MEDICINE 97,21(2018).
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