Background: Surgicel (TM) is an oxidized cellulose preparation that is widely applied in neurosurgery due to its hemostatic effect and good tissue compatibility. Tumor-like lesions induced by Surgicel (R) application in cerebral surgery have been rarely reported, especially for intracranial hemorrhage debridement surgery in patients with hypertension.
Case presentation: This case report describes a rare case in which Surgicel (TM) application led to a foreign body reaction, contributing to the development of an intracranial giant-cell granuloma. A 49-year-old female hypertensive patient was diagnosed with intracranial hemorrhage. She was treated with debridement surgery that employed Surgicel T application. Although a satisfactory hemostatic effect was achieved, the patient was diagnosed with epilepsy 6 months later. Subsequent magnetic resonance imaging revealed an intracranial space-occupying lesion. After undergoing en bloc resection of the lesion, the patient was diagnosed with a Surgicel (TM)-related intracranial giant-cell granuloma by histopathology.
Conclusions: Application of Surgicel (TM) during intracranial hemorrhage debridement surgery may be associated with a risk of granuloma development due to formation of a tumor-like space-occupying lesion in the surgery bed. Even a low risk of tumor development implies a need for caution when applying Surgicel (TM), especially when solely used to achieve a hemostatic effect.
[1]Jilin Univ, Hosp 1, Dept Neurosurg, Changchun 130021, Peoples R China.
[2]Jilin Cent Hosp, Dept Neurosurg, Nanjing 130012, Jiangsu, Peoples R China.
[3]Jilin Univ, Hosp 1, Dept Radiol, Changchun 130021, Peoples R China.
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