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Reduced cytotoxicity of silver ions to mammalian cells at high concentration due to the formation of silver chloride 期刊论文

编号：

4d2b59fa-4805-48fc-82d0-7671b1f4c52c
作者：

Zhang, Shaokun(张绍昆)#^[1]Du, Chan#^[2]Wang, Zaizhi#^[3]Han, Xinguang(韩新光)*^[4]Zhang, Kun^[5];Liu, Lihong*^[5]
语种：

英文
期刊：

TOXICOLOGY IN VITRO ISSN：0887-2333 2013 年 27 卷 2 期 (739 - 744) ; MAR
收录：
关键词：

Silver Silver chloride Cytotoxicity Hemolysis Stem cells Speciation
摘要：

Silver-containing antimicrobial agents are used in various medical products. However, their toxicity to mammalian cells has not been sufficiently evaluated. Numerous studies have unveiled evidence of significant antimicrobial properties associated with Ag ions. In cell culture media or human body fluids, the free Ag+ has rich opportunities to complex with Cl-. Surprisingly, studies on the toxicity of solid form AgCl(s) to mammalian cells are quite limited. In this study, we evaluated the cytotoxicity of Ag ions and silver chloride colloids on red blood cells and human mesenchymal stem cells (hMSCs). The adverse effects of silver chloride on red blood cells and hMSC were viewed by SEM and LIVE/DEAD viability staining, respectively. Among different tested chemical forms of silver, AgCl was identified to be the least cytotoxic. Moreover, a decline in the cytotoxicity of AgCl at significantly high concentrations was observed. We attributed the reduced cytotoxicity to aggregated AgCl which limited the bioavailability of free Ag+ ions. (C) 2012 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Zhang Shaokun,Du Chan,Wang Zaizhi, et al. Reduced cytotoxicity of silver ions to mammalian cells at high concentration due to the formation of silver chloride [J].TOXICOLOGY IN VITRO,2013,27(2):739-744.
APA：

Zhang Shaokun,Du Chan,Wang Zaizhi,Han Xinguang,&Liu Lihong.(2013).Reduced cytotoxicity of silver ions to mammalian cells at high concentration due to the formation of silver chloride .TOXICOLOGY IN VITRO,27(2):739-744.
MLA：

Zhang Shaokun, et al. "Reduced cytotoxicity of silver ions to mammalian cells at high concentration due to the formation of silver chloride" .TOXICOLOGY IN VITRO 27,2(2013):739-744.
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