Background: Brain-derived neurotrophic factor (BDNF) is a modulator of synaptic and neural plasticity. Considering the association between dystonia and abnormal sensorimotor cortex plasticity, BDNF may be a candidate gene that confers susceptibility to dystonia. However, the association between Va166Met polymorphism of BDNF gene and primary dystonia is controversial.
Methods: A case-control study was performed to evaluate the association between Va166Met polymorphism in the BDNF gene and primary dystonia in a cohort of 252 Chinese patients and in 214 age- and gender-matched healthy control subjects.
Results: No association was identified between Va166Met polymorphism and primary dystonia or cervical dystonia (P=0.309 and P=0.803 respectively). In a subsequent subgroup analysis, there was also no difference in the distribution for age of onset.
Conclusion: Our findings do not support that BDNF Va166Met polymorphism contributes to the risk of primary dystonia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurol, Beijing 100075, Peoples R China.
[2]Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China.
[3]Jilin Univ, Affiliated Hosp 1, Dept Neurol, Changchun 130021, Peoples R China.
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