Poly(acrylic acid-co-acrylamide) (P(AA-co-AM)) hydrogels with upper critical solution temperature (UCST) were synthesized via radical copolymerization technology, which were then incorporated with SiO2@polypyrrole (SiO2@PPy) for the construction of light-, thermo- and pH-responsive drug delivery system. The synthesized SiO2@PPy@P(AA-co-AM) hydrogels were then examined by Fourier transform infrared (FT-IR) spectrometry, field emission scanning electron microscopy (FESEM), thermogravimetry (TG) and differential thermogravimetric (DTG). Finally, the designed SiO2@PPy@P(AA-co-AM) hydrogels were used for controlled delivery of 5-fluorouracil (5-FU), an anti-cancer drug. An encapsulation ratio of up to 92.2% was obtained when 5-FU was encapsulated in the SiO2@PPy@P(AA-co-AM) hydrogels, and the cumulative release of 5-FU could reach 83.9% with the near-infrared (NIR) irradiation of 6 h at pH 7.4. During the controlled release of 5-FU, PPy in the system could convert the NIR irradiation to heat as a photo-thermal transducer while maintaining the temperature in the UCST range of P(AA-co-AM). In addition, SiO2 in the hydrogels acted as a gatekeeper to prevent the burst release of 5-FU.
[1]Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Mat & Technol, Changzhou 213164, Peoples R China.
[2]Jilin Univ, Hosp 1, Dept Gynecol & Obstet, Changchun 130021, Jilin, Peoples R China.
[3]Changzhou Childrens Hosp, Pneumol Dept, Changzhou 213003, Peoples R China.
(8.0+极速模式)