Our purpose was to investigate the effects of ginsenoside Rb3 (G-Rb3) on sympathetic nervous system and the RAS in acute myocardial infarction (AMI) rat. The AMI model was constructed by ligation of the anterior descending coronary artery in rats. Subsequently, the myocardial infarction size (MIS) the serum creatine kinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), plasma renin (R), and angiotensin-converting enzyme (ACE) activities, and the serum epinephrine (E), norepinephrine (NE), endothelin (ET) and angiotensin II (Ang II) levels were measured. G-Rb3 (10 and 20 mg/kg) significantly decreased the MIS, serum CK, AST, LDH, ACE and plasma renin activities, and the serum NE and epinephrine, and plasma ET and Ang II levels within 24 h after AMI in rats. These results suggested that G-Rb3 had significant protective effects in AMI rats. This action may be related with inhibition of sympathetic-adrenal medulla hyperexcitation, catecholamine (CA) secretion and RAS activation.
[1]Jilin Univ, Sch Pharm, Dept Pharmacol, Changchun 130021, Peoples R China.
[2]Jilin Univ, Sch Nursing, Changchun 130021, Peoples R China.
[3]Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
(8.0+极速模式)