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Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study 期刊论文

编号：

513776e2-1a25-4f60-a446-46ddff2f4828
作者：

Xu, LanPing(许兰平)#^[1]Wang, ShunQing(王顺清)#^[2]Wu, DePei(吴德沛)#^[3]Wang, JianMin^[4];Gao, SuJun(高素君)^[5]Jiang, Ming^[6];Wang, CunBang^[7];Zhang, Xi^[8];Liu, QiFa^[9];Xia, LingHui^[10];Wang, Xin^[11];Huang, XiaoJun(黄晓军)*^[1,12,13]
语种：

英文
期刊：

BRITISH JOURNAL OF HAEMATOLOGY ISSN：0007-1048 2016 年 175 卷 2 期 (265 - 274) ; OCT
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关键词：

severe aplastic anaemia haploidentical haematopoietic stem cell transplantation
摘要：

We conducted a prospective, multicentre study to confirm the feasibility of haplo-identical transplantation in treatment of severe aplastic anaemia (SAA) as salvage therapy, by analysing the outcomes of 101 patients who received haplo-identical transplantation between June 2012 and October 2015. All cases surviving for more than 28d achieved donor myeloid engraftment. The median time for myeloid engraftment was 12 (range, 9-25) days and 15 (range, 7-101) days for platelets, with a cumulative platelet engraftment incidence of 941 +/- 01%. With a median follow-up of 183 (30-436) months, recipients from haplo-identical transplantation had more cumulative incidence of grade II-IV acute graft-versus-host disease (aGVHD, 337% vs. 42%, P<0001), more chronic GVHD (224% vs. 66%, P=0014) at 1year, but similar grade III-IV aGVHD (79% vs. 21%, P=0157), 3-year estimated overall survival (OS, 890% vs. 910%, P=0555) and failure-free survival (FFS, 868% vs. 803%, P=0659) when compared with 48 patients who received contemporaneous transplantation from matched related donors. Multivariate analysis showed no significant difference in engraftment and survival between the two cohorts. Both OS and FFS for the entire population correlated significantly with grades III-IV aGVHD. In conclusion, haplo-identical transplantation is a feasible choice for SAA with favourable outcomes.
推荐引用方式
GB/T 7714：

Xu Lan-Ping,Wang Shun-Qing,Wu De-Pei, et al. Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study [J].BRITISH JOURNAL OF HAEMATOLOGY,2016,175(2):265-274.
APA：

Xu Lan-Ping,Wang Shun-Qing,Wu De-Pei,Wang Jian-Min,&Huang Xiao-Jun.(2016).Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study .BRITISH JOURNAL OF HAEMATOLOGY,175(2):265-274.
MLA：

Xu Lan-Ping, et al. "Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study" .BRITISH JOURNAL OF HAEMATOLOGY 175,2(2016):265-274.
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