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CDK4/6 inhibitor protects against myocardial cells apoptosis by inhibiting RB phosphorylation in H9c2 cells 期刊论文

编号：

55c72517-c272-4a8b-b72f-6ebfec5c13d7
作者：

Wang, Zhenggui(王正桂)#^[1]Li, Jing(李婧)^[1]Wang, Yonggang(王永刚)*^[1]Liu, Quan(刘全)*^[1]
语种：

英文
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2019 年 509 卷 4 期 (949 - 953) ; FEB 19
收录：
关键词：

Palbociclib High glucose Cell cycle ROS generation Apoptosis
摘要：

Cell cycle dysregulation is typical in human cancers, and CDK4/6 inhibitors targeting cell cycle have potential antiapoptosis effect. The aim of this work is to identify the regulatory effect of Palbociclib on apoptosis of H9c2 cells induced by high glucose (HG) and to elucidate the fundamental mechanisms. It was observed that Palbociclib decreased intracellular ROS production, augmented mitochondrial membrane potential and hindered apoptosis of H9c2 cells. Palbociclib increased the Bcl-2/Bax ratio, diminished the expressions of Bax and cleaved-caspase-3, and affected the RB phosphorylation and p53 expression. Altogether, the anti-apoptotic efficacy of Palbociclib could be attributed in part to the modulation of the mitochondria apoptotic pathway. (C) 2019 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Zhenggui,Li Jing,Wang Yonggang, et al. CDK4/6 inhibitor protects against myocardial cells apoptosis by inhibiting RB phosphorylation in H9c2 cells [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,509(4):949-953.
APA：

Wang Zhenggui,Li Jing,Wang Yonggang,Liu Quan.(2019).CDK4/6 inhibitor protects against myocardial cells apoptosis by inhibiting RB phosphorylation in H9c2 cells .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,509(4):949-953.
MLA：

Wang Zhenggui, et al. "CDK4/6 inhibitor protects against myocardial cells apoptosis by inhibiting RB phosphorylation in H9c2 cells" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 509,4(2019):949-953.
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