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Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice 期刊论文

编号：

5a6384a3-475f-4d75-be6e-9537ac286fab
作者：

Yin, Xia(尹霞)#^[1,2]Zhou, Shanshan(周珊珊)#^[1,2]Zheng, Yang(郑杨)*^[1]Tan, Yi^[2,3];Kong, Maiying^[4];Wang, Bo^[2,5];Feng, Wenke^[6];Epstein, Paul N.^[2];Cai, Jun*^[2]Cai, Lu^[2,3,6];
语种：

英文
期刊：

TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN：0041-008X 2014 年 277 卷 1 期 (58 - 66) ; MAY 15
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关键词：

Obstructive sleep apnea Intermittent hypoxia Metallothionein Cardiomyopathy Oxidative damage
摘要：

Obstructive sleep apnea (USA) causes chronic intermittent hypoxia (1H) to induce cardiovascular disease, which may be related to oxidative damage. Metallothionein (MT) has been extensively proved to be an endogenous and highly inducible antioxidant protein expressed in the heart. Therefore, we tested the hypotheses that oxidative stress plays a critical role in USA induced cardiac damage and MT protects the heart from OSA-induced cardiomyopathy. To mimic hypoxia/reoxygenation events that occur in adult USA patients, mice were exposed to IH for 3 days to 8 weeks. The IH paradigm consisted of alternating cycles of 20.9% O-2/8% O-2 F1O2 (30 episodes per hour) with 20s at the nadir F1O2 for 12 ha day during daylight IH significantly increased the ratio of heart weight to tibia length at 4 weeks with a decrease in cardiac function from 4 to 8 weeks. Cardiac oxidative damage and fibrosis were observed after 4 and 8 weeks of IH exposures. Endogenous MT expression was up-regulated in response to 3-day IH, but significantly decreased at 4 and 8 weeks of IH. In support of MT as a major compensatory component, mice with cardiac overexpression of MT gene and mice with global MT gene deletion were completely resistant, and highly sensitive, respectively, to chronic IH induced cardiac effects. These findings suggest that chronic 1H induces cardiomyopathy characterized by oxidative stress-mediated cardiac damage and the antioxidant MT protects the heart from such pathological and functional changes. (C) 2014 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Yin Xia,Zhou Shanshan,Zheng Yang, et al. Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice [J].TOXICOLOGY AND APPLIED PHARMACOLOGY,2014,277(1):58-66.
APA：

Yin Xia,Zhou Shanshan,Zheng Yang,Tan Yi,&Cai Lu.(2014).Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice .TOXICOLOGY AND APPLIED PHARMACOLOGY,277(1):58-66.
MLA：

Yin Xia, et al. "Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice" .TOXICOLOGY AND APPLIED PHARMACOLOGY 277,1(2014):58-66.
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