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Multiple myeloma patients with low proportion of circulating plasma cells had similar survival with primary plasma cell leukemia patients 期刊论文

编号：

5c9e134d-c595-4246-bdc7-bfaac36a3bf5
作者：

An, Gang(安刚)#^[1,2,3]Qin, Xiaoqi#^[1,2,3]Acharya, Chirag^[5,6];Xu, Yan(徐燕)^[1,2,3]Deng, Shuhui^[1,2,3];Shi, Lihui^[1,2,3];Zang, Meirong^[1,2,3];Sui, Weiwei(隋伟薇)^[1,2,3]Yi, Shuhua(易树华)^[1,2,3]Li, Zengjun(李增军)^[1,2,3]Hao, Mu(郝牧)^[1,2,3]Feng, Xiaoyan^[1,2,3];Jin, Fengyan(靳凤艳)^[4]Zou, Dehui(邹德慧)^[1,2,3]Qi, Junyuan(齐军元)^[1,2,3]Zhao, Yaozhong(赵耀中)^[1,2,3]Tai, YuTzu^[5,6]Wang, Jianxing^[1,2,3];Qiu, Lugui(邱录贵)*^[1,2,3]
语种：

英文
期刊：

ANNALS OF HEMATOLOGY ISSN：0939-5555 2015 年 94 卷 2 期 (257 - 264) ; FEB
收录：
关键词：

Multiple myeloma Circulating plasma cells Primary plasma cell leukemia
摘要：

The common features shared by primary plasma cell leukemia (pPCL) and multiple myeloma (MM) with circulating plasma cells (CPCs) are peripheral blood invasion and expansion of plasma cells independent of the protective bone marrow (BM) microenvironment niche. However, few studies have addressed the relationship between pPCL and MM with CPCs. Here, we quantitated the number CPCs by conventional morphology in 767 patients with newly diagnosed MM; their clinic features were compared with those of 33 pPCL cases. When the presence of CPCs was defined as more than 2 % plasma cells per 100 nucleated cells on Wright-Giemsa stained peripheral blood smears, the incidence of MM with CPCs was 14.1 % in newly diagnosed MM. Patients with CPCs shared many clinical features with pPCL, especially clinical parameters related to tumor burden. However, no commonalities were found in immunophenotyping and cytogenetics. The prognosis of pPCL was poor, with a median progression free survival (PFS) of 12 months and an overall survival (OS) of 15 months. MM patients with CPCs had a clearly inferior PFS and OS as compared with the control cohort. Most interestingly, although the CPCs were not high enough to meet the diagnostic criteria for pPCL, the survival of MM patients with CPCs was comparable with that of pPCL, with a median PFS of 17 months and an OS of 25 months.
推荐引用方式
GB/T 7714：

An Gang,Qin Xiaoqi,Acharya Chirag, et al. Multiple myeloma patients with low proportion of circulating plasma cells had similar survival with primary plasma cell leukemia patients [J].ANNALS OF HEMATOLOGY,2015,94(2):257-264.
APA：

An Gang,Qin Xiaoqi,Acharya Chirag,Xu Yan,&Qiu Lugui.(2015).Multiple myeloma patients with low proportion of circulating plasma cells had similar survival with primary plasma cell leukemia patients .ANNALS OF HEMATOLOGY,94(2):257-264.
MLA：

An Gang, et al. "Multiple myeloma patients with low proportion of circulating plasma cells had similar survival with primary plasma cell leukemia patients" .ANNALS OF HEMATOLOGY 94,2(2015):257-264.
入库时间：

12/16/2019 3:17:39 PM
更新时间：

12/16/2019 3:17:39 PM
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