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Synthesis and Characterization of Nanoparticles with Hydrogen Peroxide Sensitivity, Targeting and Fluorscence for Atherosclerosis 期刊论文

编号：

62b4e7b1-cd37-4ee5-8a7e-58dfbbc46cb4
作者：

Fang Chao#^[1]Zhu Hanyu^[1];Liu Ye^[1];Zhao Waiou(赵外欧)^[2]Li Yapeng(李亚鹏)*^[1]Wang Jingyuan^[1];
语种：

中文
期刊：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE ISSN：0251-0790 2018 年 39 卷 9 期 (2071 - 2079) ; SEP 10
收录：
关键词：

Amphiphilic nanoparticles Hydrogen peroxide sensitivity Drug release Fluorescent polymer Atherosclerosis
摘要：

A multifunctional nanomicelle was designed for atherosclerosis theranostics, which was synthesized by decorating the poly(2-hydroxyethyl methacrylate)(PHEMA) with simvastatin(Sim) prodrug, fluorescent polyethylene glycol(FPEG) and the macrophages targeting molecules(ISO-1). The as. obtained polymer was confirmed by nuclear magnetic resonance(H-1 NMR), Fourier transform infrared spectroscopy(FTIR) and gel permeation chromatography(GPC). The nanoparticle size and morphology were determined by dynamic light scattering(DLS) and transmission electron microscopy(TEM), which was spherical and with the size of about 100 nm. The MTT assay confirmed the biocompatibility of the nanomicelles. The targeting property was evaluated by cell uptake assay and observed via confocal laser scanning microscopy(CLSM). The results suggest that this multifunctional H2O2-respective targeting nanomicelles could become an effective tool for atherosclerosis therapy.
推荐引用方式
GB/T 7714：

Fang Chao,Zhu Hanyu,Liu Ye, 等. Synthesis and Characterization of Nanoparticles with Hydrogen Peroxide Sensitivity, Targeting and Fluorscence for Atherosclerosis [J].CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2018,39(9):2071-2079.
APA：

Fang Chao,Zhu Hanyu,Liu Ye,Zhao Waiou,&Wang Jingyuan.(2018).Synthesis and Characterization of Nanoparticles with Hydrogen Peroxide Sensitivity, Targeting and Fluorscence for Atherosclerosis .CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,39(9):2071-2079.
MLA：

Fang Chao, et al. "Synthesis and Characterization of Nanoparticles with Hydrogen Peroxide Sensitivity, Targeting and Fluorscence for Atherosclerosis" .CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 39,9(2018):2071-2079.
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