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Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect 期刊论文

编号：

657c507c-7c79-4e6a-a281-8301dd350c7a
作者：

Tang, Ying(汤赢)#^[1]Meng, ZiHui(孟子辉)#^[2]Xu, Hong(徐红)*^[1]Wu, ChangFeng(吴长锋)*^[3]
语种：

英文
期刊：

CHINESE CHEMICAL LETTERS ISSN：1001-8417 2017 年 28 卷 11 期 (2164 - 2168) ; NOV
收录：
关键词：

Photodynamic therapy Cell penetrating peptides Polymer dots Photosensitizer Cancer
摘要：

This letter describes semiconducting polymer dots (Pdots) doped with a photosensitizer and modified with a cell penetrating peptide for photodynamic therapy (PDT). The resulting Pdots exhibited efficient singlet oxygen (102) generation mediated by intraparticle energy transfer. Experimental results indicated that the peptide-coated Pdots could promote the cellular uptake and increase the penetration efficiency in vitro, and effectively suppressed tumor growth and enhanced the photodynamic effect in vivo. Our results demonstrate that Pdots with photosensitizer loading and peptide modification hold great promise for cancer therapy. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Tang Ying,Meng Zi-Hui,Xu Hong, et al. Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect [J].CHINESE CHEMICAL LETTERS,2017,28(11):2164-2168.
APA：

Tang Ying,Meng Zi-Hui,Xu Hong,Wu Chang-Feng.(2017).Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect .CHINESE CHEMICAL LETTERS,28(11):2164-2168.
MLA：

Tang Ying, et al. "Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect" .CHINESE CHEMICAL LETTERS 28,11(2017):2164-2168.
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