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Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma 期刊论文

编号：

68182b1f-9a2e-4a32-907e-1af9b2b79e7a
作者：

Zhang, Muchun(张慕淳)#^[1,2]Wang, Jinhui^[1,2];Li, Chang^[2,3];Hu, Ningning^[2,3];Wang, Kai^[2,3];Ji, Huifan(季慧范)^[2,4]He, Dongyun^[2,4];Quan, Chengshi^[5];Li, Xiao*^[2,5]Jin, Ningyi(金宁一)*^[2]Li, Yulin^[5];
语种：

English
期刊：

INTERNATIONAL JOURNAL OF ONCOLOGY ISSN：1019-6439 2013 年 42 卷 3 期 (1052 - 1060) ; MAR
收录：
关键词：

apoptin gene recombinant adenovirus PC-3 and RM-1 cells prostate cancer
摘要：

Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in various human tumor cells, but not in normal cells. To explore the use of apoptin in tumor gene therapy, we assessed a recombinant adenovirus expressing the apoptin protein (Ad-hTERTp-E1a-Apoptin) in order to determine its lethal and growth-inhibitory effects on PC-3 and RM-1 cells in vitro and its antitumor effect on solid tumors in vivo. 3[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), acridine orange (AO)/ethidium bromide (EB), 4'-6-diamidino-2-phenylindole (DAPI), and Annexin V assays showed that Ad-hTERTp-E1a-Apoptin inhibited the proliferation of PC-3 and RM-1 cells in vitro by inducing apoptosis of prostate cancer cells, and that this inhibitory effect was dose and time-dependent. In the animal models, Ad-hTERTp-E1a-Apoptin significantly inhibited tumor growth and extended the lifespan of animals. Experimental results indicate that Ad-hTERTp-E1a-Apoptin has a potential application in tumor gene therapy.
推荐引用方式
GB/T 7714：

Zhang Muchun,Wang Jinhui,Li Chang, et al. Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma [J].INTERNATIONAL JOURNAL OF ONCOLOGY,2013,42(3):1052-1060.
APA：

Zhang Muchun,Wang Jinhui,Li Chang,Hu Ningning,&Li Yulin.(2013).Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma .INTERNATIONAL JOURNAL OF ONCOLOGY,42(3):1052-1060.
MLA：

Zhang Muchun, et al. "Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma" .INTERNATIONAL JOURNAL OF ONCOLOGY 42,3(2013):1052-1060.
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