A case of hepatocellular carcinoma (HCC) with hepatic artery/hepatic vein fistula (HAHVF) is presented in this report. The patients developed a disease of a large mass with hepatic artery/hepatic vein fistula demonstrated by computed tomography (CT) scans as well as hepatic artery angiography, which had missed the chance for resection or liver transplantation. Little improvement was made after 1 time of transcatheter arterial chemoembolization (TACE) based on CT criteria. Then he was treated with radiation therapy, by which the fistula had been completely obliterated and the tumor volume reduced significantly on CT 1 Month after radiotherapy. AFP backed to nearly normal. Then TACE was performed for the second time. The hepatic artery/hepatic vein fistula was occlusion showed by hepatic artery angiography and the tumor had almost been inactivated. Now he can be the candidate for resection or transplantation.