首页 / 院系成果 / 成果详情页

Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice 期刊论文

编号：

6a351339-4623-4bde-94f0-03ddfeab8a7e
作者：

Zhang, Zhiguo(张志国)#^[1,2,3,4]Chen, Jing^[4];Zhou, Shanshan(周珊珊)^[1,2,3,4]Wang, Shudong(王树东)^[1,2,3,4]Cai, Xiaohong^[2,3];Conklin, Daniel J.^[5];Kim, KiSoo^[6];Kim, Ki Ho^[7];Tan, Yi^[2,3,4];Zheng, Yang(郑杨)*^[1]Kim, Young Heui*^[8]Cai, Lu^[2,3,4];
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES ISSN：1449-2288 2015 年 11 卷 8 期 (879 - 891) ; 2015
收录：
关键词：

Nrf2 obesity lipid accumulation lipotoxicity cardiac insulin signaling 4-O-methylhonokiol
摘要：

In obesity, cardiac insulin resistance is a putative cause of cardiac hypertrophy and dysfunction. In our previous study, we observed that Magnolia extract BL153 attenuated high-fat-diet (HFD)-induced cardiac pathogenic changes. In this study, we further investigated the protective effects of the BL153 bioactive constituent, 4-O-methylhonokiol (MH), against HFD-induced cardiac pathogenesis and its possible mechanisms. C57BL/6J mice were fed a normal diet or a HFD with gavage administration of vehicle, BL153, or MH (low or high dose) daily for 24 weeks. Treatment with MH attenuated HFD-induced obesity, as evidenced by body weight gain, and cardiac pathogenesis, as assessed by the heart weight and echocardiography. Mechanistically, MH treatment significantly reduced HFD-induced impairment of cardiac insulin signaling by preferentially augmenting Akt2 signaling. MH also inhibited cardiac expression of the inflammatory factors tumor necrosis factor-alpha and plasminogen activator inhibitor-1 and increased the phosphorylation of nuclear factor erythroid-derived 2-like 2 (Nrf2) as well as the expression of a Nrf2 downstream target gene heme oxygenase-1. The increased Nrf2 signaling was associated with decreased oxidative stress and damage, as reflected by lowered malondialdehyde and 3-nitrotyrosine levels. Furthermore, MH reduced HFD-induced cardiac lipid accumulation along with lowering expression of cardiac fatty acid translocase/CD36 protein. These results suggest that MH, a bioactive constituent of Magnolia, prevents HFD-induced cardiac pathogenesis by attenuating the impairment of cardiac insulin signaling, perhaps via activation of Nrf2 and Akt2 signaling to attenuate CD36-mediated lipid accumulation and lipotoxicity.
推荐引用方式
GB/T 7714：

Zhang Zhiguo,Chen Jing,Zhou Shanshan, et al. Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice [J].INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2015,11(8):879-891.
APA：

Zhang Zhiguo,Chen Jing,Zhou Shanshan,Wang Shudong,&Cai Lu.(2015).Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,11(8):879-891.
MLA：

Zhang Zhiguo, et al. "Magnolia Bioactive Constituent 4-O-Methylhonokiol Prevents the Impairment of Cardiac Insulin Signaling and the Cardiac Pathogenesis in High-Fat Diet-Induced Obese Mice" .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11,8(2015):879-891.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：27  下载次数：0

分享到：

浏览次数：27

下载次数：0

打印次数：0