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The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease A meta-analysis (PRISMA) of randomized control trials 期刊论文

编号：

6ae2cd39-bf47-4f42-9547-21085465adae
作者：

Zhong, Sheng#^[1,2,3]Fan, Yuxiang^[2,3];Yan, Qi^[4];Fan, Xingyu^[2];Wu, Bo^[2];Han, Yujuan^[2];Zhang, Ying^[2];Chen, Yong^[1];Zhang, Huimao(张惠茅)*^[5]Niu, Junqi(牛俊奇)^[3]
语种：

英文
期刊：

MEDICINE ISSN：0025-7974 2017 年 96 卷 49 期 ; DEC
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关键词：

combination therapy monotherapy nonalcoholic fatty liver disease pharmacological therapy silymarin
摘要：

Background: Silymarin (SIL) is an active extraction of the silybum marianum, milk thistle, which is an ancient medicinal plant for treatment of various liver diseases for centuries. This study is to assess the therapeutic effect of SIL in the treatment of nonalcoholic fatty liver disease through meta-analysis.
Methods: Published randomized controlled trials (RCTs) were included from electronic databases (PubMed, Embase, Cochrane library, Web of Science, and so forth). Cochrane handbook was applied to evaluate the methodological quality. All statistical analyses were directed by Revman 5.3 software, and statistical significance was defined as P < .05.
Results: Eight RCTs involved 587 patients were included in this study. The results showed that SIL reduced the AST and ALT levels more significantly than the control group (AST UI/L: MD = -6.57; 95% CI, -10.03 to -3.12; P =. 0002; ALT UI/L: MD = -9.16; 95% CI, -16.24 to -2.08; P =. 01). Compared with other interventions, there were significant differences decreasing AST and ALT levels when SIL was used alone (AST UI/L: MD = -5.44; 95% CI, -8.80 to -2.08; P = .002; ALT UI/L: MD = -5.08; 95% CI, -7.85 to -2.32; P = .0003).
Conclusion: SIL has positive efficacy to reduce transaminases levels in NAFLD patients. SIL can be an encouraging and considerable phytotherapy for NAFLD patients.
推荐引用方式
GB/T 7714：

Zhong Sheng,Fan Yuxiang,Yan Qi, et al. The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease A meta-analysis (PRISMA) of randomized control trials [J].MEDICINE,2017,96(49).
APA：

Zhong Sheng,Fan Yuxiang,Yan Qi,Fan Xingyu,&Niu Junqi.(2017).The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease A meta-analysis (PRISMA) of randomized control trials .MEDICINE,96(49).
MLA：

Zhong Sheng, et al. "The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease A meta-analysis (PRISMA) of randomized control trials" .MEDICINE 96,49(2017).
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